89557 20200716101538.0 doi 10.1007/s10237-019-01170-0 sideral 116093 ART-2019-116093 eng (orcid)0000-0002-4268-7424 Peña Baquedano, Juan Antonio Universidad de Zaragoza Failure damage mechanical properties of thoracic and abdominal porcine aorta layers and related constitutive modeling: phenomenological and microstructural approach 2019 Access copy available to the general public Unrestricted Despite increasing experimental and analytical efforts to investigate the irreversible effects of arterial tissue failure, the underlying mechanisms are still poorly understood. The goal of this study was to characterize the failure properties of the intact wall and each separated layer (intima, media, and adventitia) of the descending thoracic and infrarenal abdominal aorta and to test the hypothesis that the failure properties of layer-separated tissue depend on the location of the aorta. To test this hypothesis, we performed uniaxial tests to study the mechanical behavior of both intact and layer-separated porcine aortic tissue samples taken from descending thoracic and infrarenal abdominal aorta until complete failure. The fracture stress is higher in the infrarenal abdominal aorta than in the equivalent descending thoracic aorta. It was also found that the extrapolation of the elastic mechanical properties from the physiological to the supra-physiological regime for characterizing the mechanical response of the aorta would be inappropriate. Finally, we report values of constitutive parameters using phenomenological and microstructural damage models based on continuum damage mechanics theory. The phenomenological damage model gives an excellent fit to the experimental data compared to the microstructural damage model. Although the fitting results of the phenomenological model are better, the microstructural models can include physically motivated aspects obtained from experiments. info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN info:eu-repo/grantAgreement/ES/DGA/T24-17R info:eu-repo/grantAgreement/ES/MINECO/DPI2016-76630-C2-1-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.527 2019 ENGINEERING, BIOMEDICAL 42 / 87 = 0.483 2019 Q2 T2 BIOPHYSICS 34 / 71 = 0.479 2019 Q2 T2 0.85 2019 Mechanical Engineering 2019 Q1 Modeling and Simulation 2019 Q1 Biotechnology 2019 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-8375-0354 Martínez, Miguel A. Universidad de Zaragoza (orcid)0000-0002-0664-5024 Peña, Estefanía Universidad de Zaragoza 5002 305 Universidad de Zaragoza Dpto. Ingeniería Diseño Fabri. Área Expresión Gráfica en Ing. 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 18, 6 (2019), 1709-1730 Biomech. model. mechanobiol. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 1617-7959 2623318 http://zaguan.unizar.es/record/89557/files/texto_completo.pdf Postprint 497949 http://zaguan.unizar.es/record/89557/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:89557 articulos driver 2020-07-16-09:38:36 ARTICLE