Effect of Lifestyle Intervention in the Concentration of Adipoquines and Branched Chain Amino Acids in Subjects with High Risk of Developing Type 2 Diabetes: Feel4Diabetes Study

Lamiquiz-Moneo, I. ; Bea, A.M. ; Palacios-Perez, C. ; De Miguel-Etayo, P. ; Gonzalez-Gil, E.M. ; Lopez-Arino, C. ; Civeira, F. (Universidad de Zaragoza) ; Moreno, L.A. (Universidad de Zaragoza) ; Mateo-Gallego, R. (Universidad de Zaragoza)

Resumen: Introduction: The global prevalence of type 2 diabetes (T2D) is increasing rapidly, especially in low- and middle-income countries and has a high number of associated comorbidities. Plasmatic concentrations of branched chain amino acids (BCAA) and retinol-binding protein 4 (RBP4) have been shown to be elevated in T2D subjects in cross-sectional studies. However, the effect of lifestyle community-based interventions on BCAA and RBP4 concentrations has not yet been analyzed.
Material and methods: The Feel4Diabetes study is a school and community-based intervention that identified 360 European families with a high risk of developing T2D according to the FINDRISC questionnaire. Families were randomized in control and intervention groups were followed-up from 2016 to 2018. In the Spanish families, the concentration of BCAA and RBP4 was determined in 266 subjects (115 control and 151 intervention group) that attended the three time-point assessments by colorimetric and ELISA reaction, respectively.
Results: Baseline BCAA levels showed positive correlations with the FINDRISC score and glucose impairment (baseline glucose, insulin, and glycated hemoglobin), body mass index, and body weight. The participants receiving the community-based intervention showed a significant decrease in glycated hemoglobin and BCAA levels compared to the control group (p = 0.011 and p < 0.001, respectively). However, baseline RBP4 did not show significant correlations with anthropometric and glycemic parameters, and no significant change was observed in anthropometric parameters and RBP4 concentrations throughout the follow-up.
Conclusion: A community-based intervention on lifestyle led to a significant reduction in BCAA levels regardless of weight loss. These findings suggest that this interventional approach could be promising in T2D prevention.

Idioma: Inglés

DOI: 10.3390/cells9030693

Año: 2020

Publicado en: Cells 9, 3 (2020), 693 [19 pp]
ISSN: 2073-4409

Factor impacto JCR: 6.6 (2020)

Categ. JCR: CELL BIOLOGY rank: 53 / 195 = 0.272 (2020) - Q2 - T1

Factor impacto SCIMAGO: 1.22 - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B14-7R
Financiación: info:eu-repo/grantAgreement/ES/FEDER/Una manera de hacer Europa
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CIBERCV
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PI15-01983
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PI18-01777

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)