89590 20230201140446.0 doi 10.3390/cells9030693 sideral 117619 ART-2020-117619 eng Lamiquiz-Moneo, I. (orcid)0000-0002-9647-0108 Effect of Lifestyle Intervention in the Concentration of Adipoquines and Branched Chain Amino Acids in Subjects with High Risk of Developing Type 2 Diabetes: Feel4Diabetes Study 2020 Access copy available to the general public Unrestricted Introduction: The global prevalence of type 2 diabetes (T2D) is increasing rapidly, especially in low- and middle-income countries and has a high number of associated comorbidities. Plasmatic concentrations of branched chain amino acids (BCAA) and retinol-binding protein 4 (RBP4) have been shown to be elevated in T2D subjects in cross-sectional studies. However, the effect of lifestyle community-based interventions on BCAA and RBP4 concentrations has not yet been analyzed. Material and methods: The Feel4Diabetes study is a school and community-based intervention that identified 360 European families with a high risk of developing T2D according to the FINDRISC questionnaire. Families were randomized in control and intervention groups were followed-up from 2016 to 2018. In the Spanish families, the concentration of BCAA and RBP4 was determined in 266 subjects (115 control and 151 intervention group) that attended the three time-point assessments by colorimetric and ELISA reaction, respectively. Results: Baseline BCAA levels showed positive correlations with the FINDRISC score and glucose impairment (baseline glucose, insulin, and glycated hemoglobin), body mass index, and body weight. The participants receiving the community-based intervention showed a significant decrease in glycated hemoglobin and BCAA levels compared to the control group (p = 0.011 and p < 0.001, respectively). However, baseline RBP4 did not show significant correlations with anthropometric and glycemic parameters, and no significant change was observed in anthropometric parameters and RBP4 concentrations throughout the follow-up. Conclusion: A community-based intervention on lifestyle led to a significant reduction in BCAA levels regardless of weight loss. These findings suggest that this interventional approach could be promising in T2D prevention. info:eu-repo/grantAgreement/ES/DGA/B14-7R info:eu-repo/grantAgreement/ES/FEDER/Una manera de hacer Europa info:eu-repo/grantAgreement/ES/MINECO/CIBERCV info:eu-repo/grantAgreement/ES/MINECO/PI15-01983 info:eu-repo/grantAgreement/ES/MINECO/PI18-01777 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.6 2020 CELL BIOLOGY 53 / 195 = 0.272 2020 Q2 T1 1.22 2020 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bea, A.M. Palacios-Perez, C. De Miguel-Etayo, P. Gonzalez-Gil, E.M. Lopez-Arino, C. Civeira, F. Universidad de Zaragoza (orcid)0000-0001-7043-0952 Moreno, L.A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Mateo-Gallego, R. Universidad de Zaragoza (orcid)0000-0001-6650-8294 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 9, 3 (2020), 693 [19 pp] Cells Cells 2073-4409 384960 http://zaguan.unizar.es/record/89590/files/texto_completo.pdf Versión publicada 511723 http://zaguan.unizar.es/record/89590/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89590 articulos driver 2023-02-01-13:46:54 ARTICLE