000089658 001__ 89658
000089658 005__ 20230126102838.0
000089658 0247_ $$2doi$$a10.1186/s12967-020-02352-6
000089658 0248_ $$2sideral$$a117760
000089658 037__ $$aART-2020-117760
000089658 041__ $$aeng
000089658 100__ $$aGoris, N.A.V.
000089658 245__ $$aEfficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma: experiment and mathematical modeling
000089658 260__ $$c2020
000089658 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089658 5203_ $$aBACKGROUND: The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the tumor long axis. The aim of this work is to evaluate the efficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma that grow in the male and female BALB/c/Cenp mice, when multiple-straight needle electrodes and multiple-pairs of electrodes are inserted in the tumor. METHODS: A longitudinal and retrospective preclinical study was carried out. Male and female BALB/c/Cenp mice, the modified Gompertz equation, intensities (2, 6 and 10 mA) and exposure times (10 and 20 min) of direct current, and three geometries of multiple-electrodes (one formed by collinear electrodes and two by pair-electrodes) were used. Tumor volume and mice weight were measured. In addition, the mean tumor doubling time, tumor regression percentage, tumor growth delay, direct current overall effectiveness and mice survival were calculated. RESULTS: The greatest growth retardation, mean doubling time, regression percentage and growth delay of the primary F3II mammary carcinoma in male and female mice were observed when the geometry of multiple-pairs of electrodes was arranged in the tumor at 45, 135, 225 and 325o and the longest exposure time. In addition, highest direct current overall effectiveness (above 66%) was observed for this EChT scheme. CONCLUSIONS: It is concluded that electrochemical therapy may be potentially addressed to highly aggressive and metastic primary F3II murine mammary carcinoma and the modified Gompertz equation may be used to fit data of this direct current treated carcinoma. Additionally, electrochemical therapy effectiveness depends on the exposure time, geometry of multiple-electrodes and ratio between the direct current intensity applied and the polarization current induced in the tumor.
000089658 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089658 590__ $$a5.531$$b2020
000089658 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b41 / 140 = 0.293$$c2020$$dQ2$$eT1
000089658 592__ $$a1.576$$b2020
000089658 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000089658 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2020$$dQ1
000089658 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089658 700__ $$aRodríguez, J.L.G.
000089658 700__ $$aGonzález, M.M.
000089658 700__ $$aBorges, B.O.
000089658 700__ $$aMorales, D.F.
000089658 700__ $$aCalzado, E.M.
000089658 700__ $$aCastañeda, A.R.S.
000089658 700__ $$aTorres, L.M.
000089658 700__ $$0(orcid)0000-0001-6120-4427$$aMontijano, J.I.$$uUniversidad de Zaragoza
000089658 700__ $$aGonzález, V.G.S.
000089658 700__ $$aPérez, D.J.
000089658 700__ $$aPosada, O.O.
000089658 700__ $$aMartínez, J.A.
000089658 700__ $$aDelgado, A.G.
000089658 700__ $$aMartínez, K.G.
000089658 700__ $$aMon, M.L.
000089658 700__ $$aMonzón, K.L.
000089658 700__ $$aCiria, H.M.C.
000089658 700__ $$aCabrales, L.E.B.
000089658 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000089658 773__ $$g18 (2020), 190 [17 pp.]$$pJournal of Translational Medicine$$tJournal of translational medicine$$x1479-5876
000089658 8564_ $$s1835149$$uhttps://zaguan.unizar.es/record/89658/files/texto_completo.pdf$$yVersión publicada
000089658 8564_ $$s40297$$uhttps://zaguan.unizar.es/record/89658/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089658 909CO $$ooai:zaguan.unizar.es:89658$$particulos$$pdriver
000089658 951__ $$a2023-01-26-09:55:21
000089658 980__ $$aARTICLE