000089664 001__ 89664
000089664 005__ 20210902121702.0
000089664 0247_ $$2doi$$a10.3390/ijms21093231
000089664 0248_ $$2sideral$$a117768
000089664 037__ $$aART-2020-117768
000089664 041__ $$aeng
000089664 100__ $$0(orcid)0000-0001-9773-7460$$aGuijarro, Isabel M.$$uUniversidad de Zaragoza
000089664 245__ $$aAssessment of glial activation response in the progress of natural scrapie after chronic dexamethasone treatment
000089664 260__ $$c2020
000089664 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089664 5203_ $$aNeuroinflammation has been correlated with the progress of neurodegeneration in many neuropathologies. Although glial cells have traditionally been considered to be protective, the concept of them as neurotoxic cells has recently emerged. Thus, a major unsolved question is the exact role of astroglia and microglia in neurodegenerative disorders. On the other hand, it is well known that glucocorticoids are the first choice to regulate inflammation and, consequently, neuroglial inflammatory activity. The objective of this study was to determine how chronic dexamethasone treatment influences the host immune response and to characterize the beneficial or detrimental role of glial cells. To date, this has not been examined using a natural neurodegenerative model of scrapie. With this aim, immunohistochemical expression of glial markers, prion protein accumulation, histopathological lesions and clinical evolution were compared with those in a control group. The results demonstrated how the complex interaction between glial populations failed to compensate for brain damage in natural conditions, emphasizing the need for using natural models. Additionally, the data showed that modulation of neuroinflammation by anti-inflammatory drugs might become a research focus as a potential therapeutic target for prion diseases, similar to that considered previously for other neurodegenerative disorders classified as prion-like diseases.
000089664 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU15-03524$$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION
000089664 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089664 590__ $$a5.923$$b2020
000089664 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b67 / 297 = 0.226$$c2020$$dQ1$$eT1
000089664 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b49 / 178 = 0.275$$c2020$$dQ2$$eT1
000089664 592__ $$a1.455$$b2020
000089664 593__ $$aCatalysis$$c2020$$dQ1
000089664 593__ $$aComputer Science Applications$$c2020$$dQ1
000089664 593__ $$aInorganic Chemistry$$c2020$$dQ1
000089664 593__ $$aSpectroscopy$$c2020$$dQ1
000089664 593__ $$aMolecular Biology$$c2020$$dQ1
000089664 593__ $$aOrganic Chemistry$$c2020$$dQ1
000089664 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000089664 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000089664 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089664 700__ $$0(orcid)0000-0002-1756-5492$$aGarcés, Moisés$$uUniversidad de Zaragoza
000089664 700__ $$aAndrés-Benito, Pol
000089664 700__ $$0(orcid)0000-0002-1590-3347$$aMarín, Belén$$uUniversidad de Zaragoza
000089664 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, Alicia$$uUniversidad de Zaragoza
000089664 700__ $$0(orcid)0000-0002-7037-6316$$aBarrio, Tomás
000089664 700__ $$aCarmona, Margarita
000089664 700__ $$aFerrer, Isidro
000089664 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, Juan J.$$uUniversidad de Zaragoza
000089664 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, Marta$$uUniversidad de Zaragoza
000089664 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000089664 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000089664 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000089664 773__ $$g21, 9 (2020), 3231 [23 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000089664 8564_ $$s4684720$$uhttps://zaguan.unizar.es/record/89664/files/texto_completo.pdf$$yVersión publicada
000089664 8564_ $$s507007$$uhttps://zaguan.unizar.es/record/89664/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000089664 951__ $$a2021-09-02-09:15:07
000089664 980__ $$aARTICLE