000089674 001__ 89674 000089674 005__ 20220617151028.0 000089674 0247_ $$2doi$$a10.3390/ijms21093374 000089674 0248_ $$2sideral$$a117791 000089674 037__ $$aART-2020-117791 000089674 041__ $$aeng 000089674 100__ $$0(orcid)0000-0003-0145-3020$$aGarrido-Pérez, Nuria$$uUniversidad de Zaragoza 000089674 245__ $$aOxidative phosphorylation dysfunction modifies the cell secretome 000089674 260__ $$c2020 000089674 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089674 5203_ $$aMitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell’s secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials. 000089674 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B33-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-0122 000089674 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089674 590__ $$a5.923$$b2020 000089674 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b67 / 297 = 0.226$$c2020$$dQ1$$eT1 000089674 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b49 / 178 = 0.275$$c2020$$dQ2$$eT1 000089674 592__ $$a1.455$$b2020 000089674 593__ $$aCatalysis$$c2020$$dQ1 000089674 593__ $$aComputer Science Applications$$c2020$$dQ1 000089674 593__ $$aInorganic Chemistry$$c2020$$dQ1 000089674 593__ $$aSpectroscopy$$c2020$$dQ1 000089674 593__ $$aMolecular Biology$$c2020$$dQ1 000089674 593__ $$aOrganic Chemistry$$c2020$$dQ1 000089674 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1 000089674 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000089674 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000089674 700__ $$aVela-Sebastián, Ana$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, Ester$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0001-5964-6138$$aEmperador, Sonia$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0003-1508-6516$$aIglesias, Eldris$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0002-3587-6622$$aMeade, Patricia$$uUniversidad de Zaragoza 000089674 700__ $$aJiménez-Mallebrera, Cecilia 000089674 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, Julio$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0002-8585-6371$$aBayona-Bafaluy, M. Pilar$$uUniversidad de Zaragoza 000089674 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, Eduardo$$uUniversidad de Zaragoza 000089674 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología 000089674 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000089674 773__ $$g21, 9 (2020), 3374 [16 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596 000089674 8564_ $$s852023$$uhttps://zaguan.unizar.es/record/89674/files/texto_completo.pdf$$yVersión publicada 000089674 8564_ $$s467784$$uhttps://zaguan.unizar.es/record/89674/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089674 909CO $$ooai:zaguan.unizar.es:89674$$particulos$$pdriver 000089674 951__ $$a2022-06-17-15:02:48 000089674 980__ $$aARTICLE