89674 20220617151028.0 doi 10.3390/ijms21093374 sideral 117791 ART-2020-117791 eng Garrido-Pérez, Nuria Universidad de Zaragoza (orcid)0000-0003-0145-3020 Oxidative phosphorylation dysfunction modifies the cell secretome 2020 Access copy available to the general public Unrestricted Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell’s secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials. info:eu-repo/grantAgreement/ES/DGA/B33-17R info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021 info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166 info:eu-repo/grantAgreement/ES/ISCIII/PI19-0122 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.923 2020 BIOCHEMISTRY & MOLECULAR BIOLOGY 67 / 297 = 0.226 2020 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 49 / 178 = 0.275 2020 Q2 T1 1.455 2020 Catalysis 2020 Q1 Computer Science Applications 2020 Q1 Inorganic Chemistry 2020 Q1 Spectroscopy 2020 Q1 Molecular Biology 2020 Q1 Organic Chemistry 2020 Q1 Physical and Theoretical Chemistry 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Vela-Sebastián, Ana Universidad de Zaragoza López-Gallardo, Ester Universidad de Zaragoza (orcid)0000-0002-3217-1424 Emperador, Sonia Universidad de Zaragoza (orcid)0000-0001-5964-6138 Iglesias, Eldris Universidad de Zaragoza (orcid)0000-0003-1508-6516 Meade, Patricia Universidad de Zaragoza (orcid)0000-0002-3587-6622 Jiménez-Mallebrera, Cecilia Montoya, Julio Universidad de Zaragoza (orcid)0000-0003-1770-6299 Bayona-Bafaluy, M. Pilar Universidad de Zaragoza (orcid)0000-0002-8585-6371 Ruiz-Pesini, Eduardo Universidad de Zaragoza (orcid)0000-0002-0269-7337 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 21, 9 (2020), 3374 [16 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 852023 http://zaguan.unizar.es/record/89674/files/texto_completo.pdf Versión publicada 467784 http://zaguan.unizar.es/record/89674/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89674 articulos driver 2022-06-17-15:02:48 ARTICLE