000089676 001__ 89676
000089676 005__ 20210902121706.0
000089676 0247_ $$2doi$$a10.1039/d0ra00931h
000089676 0248_ $$2sideral$$a117796
000089676 037__ $$aART-2020-117796
000089676 041__ $$aeng
000089676 100__ $$aBastami, T.R.
000089676 245__ $$aSonochemical synthesis of polyoxometalate-stabilized gold nanoparticles for point-of-care determination of acetaminophen levels: preclinical study in an animal model
000089676 260__ $$c2020
000089676 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089676 5203_ $$aThe aim of this study is the accurate and rapid detection of acetaminophen (AP) for point-of-care (POC) clinical diagnosis. Acetaminophen overdose causes acute liver failure and currently there is a lack of rapid quantitative detection methods for this drug in the emergency room. Here, low-frequency sonication (20 kHz) in the presence of phosphomolybdic acid (PMo12) was used to reduce Au3+to Au0and stabilize the resulting spherical Au0nanoparticles (herein AuNPs). These AuNPs@PMo12were used as nano-probes for the selective detection of acetaminophen in the presence of other commercial drugs. The optical sensing method we describe is based on the aggregation of AuNPs@PMo12in the presence of acetaminophen, which produces a red-shift in the absorption spectrum of the AuNPs@PMo12, which is characterised by a color change from red to purple that is visible to the naked eye. Furthermore, the quantitative determination of acetaminophen concentrations can be carried out using the eyedropper function in Microsoft''s PowerPoint or open access ImageJ software, using RGB (red, green, and blue) values. To prove the feasibility of this novel nanosensor, the concentration of acetaminophen was measured in over-the-counter pharmaceutical tablets and in serum samples taken from mice. This simple sensing approach offers high stability, selectivity, rapid detection time, and cost saving compared to other detection methods, which therefore opens the way for the development of quantitative POC acetaminophen detection using polyoxometalate-stabilized metal nanoparticles.
000089676 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000089676 590__ $$a3.361$$b2020
000089676 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b81 / 178 = 0.455$$c2020$$dQ2$$eT2
000089676 592__ $$a0.746$$b2020
000089676 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1
000089676 593__ $$aChemical Engineering (miscellaneous)$$c2020$$dQ1
000089676 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089676 700__ $$aGhaedi, A.
000089676 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, S.G.$$uUniversidad de Zaragoza
000089676 700__ $$aJavadian-Saraf, A.
000089676 700__ $$aKarimi, M.
000089676 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000089676 773__ $$g10, 28 (2020), 16805-16816$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000089676 8564_ $$s2769867$$uhttps://zaguan.unizar.es/record/89676/files/texto_completo.pdf$$yVersión publicada
000089676 8564_ $$s59794$$uhttps://zaguan.unizar.es/record/89676/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089676 909CO $$ooai:zaguan.unizar.es:89676$$particulos$$pdriver
000089676 951__ $$a2021-09-02-09:17:26
000089676 980__ $$aARTICLE