000089686 001__ 89686 000089686 005__ 20230914083302.0 000089686 0247_ $$2doi$$a10.3389/fmed.2020.00126 000089686 0248_ $$2sideral$$a117813 000089686 037__ $$aART-2020-117813 000089686 041__ $$aeng 000089686 100__ $$aGarcía-Rayado, G. 000089686 245__ $$aDietary fat patterns and outcomes in acute pancreatitis in Spain 000089686 260__ $$c2020 000089686 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089686 5203_ $$aBackground/Objective: Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP). Objective: The aim of this study was to analyze outcomes in patients with AP from regions in Spain with different patterns of dietary fat intake. Materials and Methods: A retrospective analysis was performed with data from 1, 655 patients with AP from a Spanish prospective cohort study and regional nutritional data from a Spanish cross-sectional study. Nutritional data considered in the study concern the total lipid consumption, detailing total saturated fatty acids, UFAs and monounsaturated fatty acids (MUFAs) consumption derived from regional data and not from the patient prospective cohort. Two multivariable analysis models were used: (1) a model with the Charlson comorbidity index, sex, alcoholic etiology, and recurrent AP; (2) a model that included these variables plus obesity. Results: In multivariable analysis, patients from regions with high UFA intake had a significantly increased frequency of local complications, persistent organ failure (POF), mortality, and moderate-to-severe disease in the model without obesity and a higher frequency of POF in the model with obesity. Patients from regions with high MUFA intake had significantly more local complications and moderate-to-severe disease; this significance remained for moderate-to-severe disease when obesity was added to the model. Conclusions: Differences in dietary fat patterns could be associated with different outcomes in AP, and dietary fat patterns may be a pre-morbid factor that determines the severity of AP. UFAs, and particulary MUFAs, may influence the pathogenesis of the severity of AP. 000089686 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CM17-00145 000089686 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089686 590__ $$a5.091$$b2020 000089686 591__ $$aMEDICINE, GENERAL & INTERNAL$$b28 / 167 = 0.168$$c2020$$dQ1$$eT1 000089686 592__ $$a1.387$$b2020 000089686 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000089686 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089686 700__ $$aVarela-Moreiras, G. 000089686 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Á.$$uUniversidad de Zaragoza 000089686 700__ $$0(orcid)0000-0003-2280-9372$$aFerrández, Á.$$uUniversidad de Zaragoza 000089686 700__ $$aBalza-Lareu, N. 000089686 700__ $$aCervera, J.I. 000089686 700__ $$aBodenlle-Bello, M.P. 000089686 700__ $$aArgüelles-Arias, A.M. 000089686 700__ $$aLatorre, P. 000089686 700__ $$aUdaondo-Cascante, M.A. 000089686 700__ $$aSoria-de-la-Cruz, M.J. 000089686 700__ $$aLariño-Noia, J. 000089686 700__ $$aGarcía-Figueiras, R. 000089686 700__ $$aGil-García-Ollauri, C. 000089686 700__ $$aItuarte-Uriarte, R. 000089686 700__ $$aRosales-Alexander, C.L. 000089686 700__ $$aSoriano, J. 000089686 700__ $$aRodríguez-Peláez, M. 000089686 700__ $$aMesa-Álvarez, A. 000089686 700__ $$aOblitas, E. 000089686 700__ $$aMenso, M.M. 000089686 700__ $$aBertoletti, F. 000089686 700__ $$aRodríguez-Prada, J.I. 000089686 700__ $$aGuzmán-Suárez, S. 000089686 700__ $$aClosa, D. 000089686 700__ $$ade-Madaria, E. 000089686 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000089686 773__ $$g7, 126 (2020), 1-7$$pFront. med.$$tFrontiers in Medicine$$x2296-858X 000089686 8564_ $$s169741$$uhttps://zaguan.unizar.es/record/89686/files/texto_completo.pdf$$yVersión publicada 000089686 8564_ $$s29050$$uhttps://zaguan.unizar.es/record/89686/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089686 909CO $$ooai:zaguan.unizar.es:89686$$particulos$$pdriver 000089686 951__ $$a2023-09-13-10:53:57 000089686 980__ $$aARTICLE