89694 20210902121710.0 doi 10.3390/nano10040616 sideral 117828 ART-2020-117828 eng Gámez, Enrique (orcid)0000-0002-0272-3152 Antibacterial effect of thymol loaded SBA-15 nanorods incorporated in PCL electrospun fibers 2020 Access copy available to the general public Unrestricted For the effective management of infected chronic wounds, the incorporation of antimicrobial drugs into wound dressings can increase their local availability at the infection site. Mesoporous silicon dioxide SBA-15 is an excellent drug carrier with tunable drug release kinetics. In this work, synthesized SBA-15 loaded with the natural antimicrobial compound thymol (THY) was incorporated into polycaprolactone (PCL) electrospun nanofibers to obtain an advanced wound dressing. Rod-shaped particles with internal parallel channels oriented along the longitudinal axis (diameter: 138 ± 30 nm, length: 563 ± 100 nm) were loaded with 70.8 wt.% of THY. Fiber mats were prepared using these particles as nanofillers within polycaprolactone (PCL) electrospun fibers. The resulting mats contained 5.6 wt.% of THY and more than half of this loading was released in the first 7 h. This release would prevent an initial bacterial colonization and also inhibit or eliminate bacterial growth as in vitro shown against Staphylococcus aureus ATCC 25923. Minimal inhibitory concentration (MIC: 0.07 mg/mL) and minimal bactericidal concentration (MBC: 0.11 mg/mL) of released THY were lower than the amount of free THY required, demonstrating the benefit of drug encapsulation for a more efficient bactericidal capacity due to the direct contact between mats and bacteria. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.076 2020 PHYSICS, APPLIED 35 / 160 = 0.219 2020 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 51 / 106 = 0.481 2020 Q2 T2 CHEMISTRY, MULTIDISCIPLINARY 55 / 178 = 0.309 2020 Q2 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 103 / 333 = 0.309 2020 Q2 T1 0.919 2020 Materials Science (miscellaneous) 2020 Q1 Chemical Engineering (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Elizondo-Castillo, Hellen Tascon, Jorge García-Salinas, Sara Universidad de Zaragoza (orcid)0000-0002-0595-5514 Navascues, Nuria (orcid)0000-0003-3363-2912 Mendoza, Gracia Universidad de Zaragoza (orcid)0000-0003-2293-363X Arruebo, Manuel Universidad de Zaragoza (orcid)0000-0003-3165-0156 Irusta, Silvia Universidad de Zaragoza (orcid)0000-0002-2966-9088 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 10, 4 (2020), 616 [13 pp.] Nanomaterials (Basel) Nanomaterials 2079-4991 961301 http://zaguan.unizar.es/record/89694/files/texto_completo.pdf Versión publicada 472331 http://zaguan.unizar.es/record/89694/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89694 articulos driver 2021-09-02-09:20:17 ARTICLE