000089700 001__ 89700
000089700 005__ 20210902121656.0
000089700 0247_ $$2doi$$a10.1371/journal.ppat.1008404
000089700 0248_ $$2sideral$$a117836
000089700 037__ $$aART-2020-117836
000089700 041__ $$aeng
000089700 100__ $$0(orcid)0000-0002-3086-3013$$aTarancón, Raquel$$uUniversidad de Zaragoza
000089700 245__ $$aNew live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia
000089700 260__ $$c2020
000089700 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089700 5203_ $$aAmong infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis, have been related not only to specific induction of T-cell immunity, but also with the long-term epigenetic and metabolic reprogramming of the cells from the innate immune system through a process termed trained immunity. Here we show that MTBVAC, a live attenuated strain of Mycobacterium tuberculosis, safe and immunogenic against tuberculosis antigens in adults and newborns, is also able to generate trained immunity through the induction of glycolysis and glutaminolysis and the accumulation of histone methylation marks at the promoters of proinflammatory genes, facilitating an enhanced response after secondary challenge with non-related bacterial stimuli. Importantly, these findings in human primary myeloid cells are complemented by a strong MTBVAC-induced heterologous protection against a lethal challenge with Streptococcus pneumoniae in an experimental murine model of pneumonia.
000089700 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097625-B-100
000089700 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089700 590__ $$a6.823$$b2020
000089700 591__ $$aMICROBIOLOGY$$b20 / 136 = 0.147$$c2020$$dQ1$$eT1
000089700 591__ $$aVIROLOGY$$b7 / 36 = 0.194$$c2020$$dQ1$$eT1
000089700 591__ $$aPARASITOLOGY$$b3 / 38 = 0.079$$c2020$$dQ1$$eT1
000089700 592__ $$a3.718$$b2020
000089700 593__ $$aGenetics$$c2020$$dQ1
000089700 593__ $$aImmunology$$c2020$$dQ1
000089700 593__ $$aVirology$$c2020$$dQ1
000089700 593__ $$aMolecular Biology$$c2020$$dQ1
000089700 593__ $$aParasitology$$c2020$$dQ1
000089700 593__ $$aMicrobiology$$c2020$$dQ1
000089700 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089700 700__ $$aDomínguez-Andrés, Jorge
000089700 700__ $$0(orcid)0000-0001-7866-2803$$aUranga, Santiago$$uUniversidad de Zaragoza
000089700 700__ $$aFerreira, Anaísa V.
000089700 700__ $$aGroh, Laszlo A.
000089700 700__ $$aDomenech, Mirian
000089700 700__ $$aGonzález-Camacho, Fernando
000089700 700__ $$aRiksen, Niels P.
000089700 700__ $$0(orcid)0000-0001-7897-9173$$aAguilo, Nacho$$uUniversidad de Zaragoza
000089700 700__ $$aYuste, José
000089700 700__ $$0(orcid)0000-0003-2993-5478$$aMartín, Carlos$$uUniversidad de Zaragoza
000089700 700__ $$aNetea, Mihai G.
000089700 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000089700 7102_ $$11011$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cProy. investigación HQA
000089700 773__ $$g16, 4 (2020), e1008404 [18 pp.]$$pPLoS Pathog.$$tPLoS Pathogens$$x1553-7366
000089700 8564_ $$s2271468$$uhttps://zaguan.unizar.es/record/89700/files/texto_completo.pdf$$yVersión publicada
000089700 8564_ $$s487332$$uhttps://zaguan.unizar.es/record/89700/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089700 909CO $$ooai:zaguan.unizar.es:89700$$particulos$$pdriver
000089700 951__ $$a2021-09-02-09:10:13
000089700 980__ $$aARTICLE