89700 20210902121656.0 doi 10.1371/journal.ppat.1008404 sideral 117836 ART-2020-117836 eng Tarancón, Raquel Universidad de Zaragoza (orcid)0000-0002-3086-3013 New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia 2020 Access copy available to the general public Unrestricted Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis, have been related not only to specific induction of T-cell immunity, but also with the long-term epigenetic and metabolic reprogramming of the cells from the innate immune system through a process termed trained immunity. Here we show that MTBVAC, a live attenuated strain of Mycobacterium tuberculosis, safe and immunogenic against tuberculosis antigens in adults and newborns, is also able to generate trained immunity through the induction of glycolysis and glutaminolysis and the accumulation of histone methylation marks at the promoters of proinflammatory genes, facilitating an enhanced response after secondary challenge with non-related bacterial stimuli. Importantly, these findings in human primary myeloid cells are complemented by a strong MTBVAC-induced heterologous protection against a lethal challenge with Streptococcus pneumoniae in an experimental murine model of pneumonia. info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097625-B-100 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.823 2020 MICROBIOLOGY 20 / 136 = 0.147 2020 Q1 T1 VIROLOGY 7 / 36 = 0.194 2020 Q1 T1 PARASITOLOGY 3 / 38 = 0.079 2020 Q1 T1 3.718 2020 Genetics 2020 Q1 Immunology 2020 Q1 Virology 2020 Q1 Molecular Biology 2020 Q1 Parasitology 2020 Q1 Microbiology 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Domínguez-Andrés, Jorge Uranga, Santiago Universidad de Zaragoza (orcid)0000-0001-7866-2803 Ferreira, Anaísa V. Groh, Laszlo A. Domenech, Mirian González-Camacho, Fernando Riksen, Niels P. Aguilo, Nacho Universidad de Zaragoza (orcid)0000-0001-7897-9173 Yuste, José Martín, Carlos Universidad de Zaragoza (orcid)0000-0003-2993-5478 Netea, Mihai G. 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1011 X Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Proy. investigación HQA 16, 4 (2020), e1008404 [18 pp.] PLoS Pathog. PLoS Pathogens 1553-7366 2271468 http://zaguan.unizar.es/record/89700/files/texto_completo.pdf Versión publicada 487332 http://zaguan.unizar.es/record/89700/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89700 articulos driver 2021-09-02-09:10:13 ARTICLE