000089712 001__ 89712 000089712 005__ 20210902121634.0 000089712 0247_ $$2doi$$a10.5424/sjar/2020181-15411 000089712 0248_ $$2sideral$$a117575 000089712 037__ $$aART-2020-117575 000089712 041__ $$aeng 000089712 100__ $$aAlonso, I. 000089712 245__ $$aGenomic differentiation among varieties of Iberian pig 000089712 260__ $$c2020 000089712 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089712 5203_ $$aAim of study: The objective of this study was to identify the autosomal genomic regions associated with genetic differentiation between three commercial strains of Iberian pig. Area of study: Extremadura (Spain). Material and methods: We used the Porcine v2 BeadChip to genotype 349 individuals from three varieties of Iberian pig (EE, Entrepelado; RR, Retinto; and TT, Torbiscal) and their crosses. After standard filtering of the Single Nucleotide Polymorphism (SNP) markers, 47, 67, and 123 haplotypic phases from EE, RR, and TT origins were identified. The allelic frequencies of 31, 180 SNP markers were used to calculate the fixation index (FST) that were averaged in sliding windows of 2Mb. Main results: The results confirmed the greater genetic closeness of the EE and RR varieties, and we were able to identify several genomic regions with a divergence greater than expected. The genes present in those genomic regions were used to perform an Overrepresentation Enrichment Analysis (ORA) for the Gene Ontology (GO) terms for biological process. The ORA indicated that several groups of biological processes were overrepresented: a large group involving morphogenesis and development, and others associated with neurogenesis, cellular responses, or metabolic processes. These results were reinforced by the presence of some genes within the genomic regions that had the highest genomic differentiation. Research highlights: The genomic differentiation among varieties of the Iberian pig is heterogeneous along the genome. The genomic regions with the highest differentiation contain an overrepresentation of genes related with morphogenesis and develop-ment, neurogenesis, cellular responses and metabolic processes. 000089712 536__ $$9info:eu-repo/grantAgreement/ES/INIA/RTA2015-00054-C02-01$$9info:eu-repo/grantAgreement/ES/MCIU-CDTI/IDI-20170304$$9info:eu-repo/grantAgreement/ES/MCIU/CGL2016-80155 000089712 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089712 590__ $$a1.238$$b2020 000089712 591__ $$aAGRICULTURE, MULTIDISCIPLINARY$$b31 / 58 = 0.534$$c2020$$dQ3$$eT2 000089712 592__ $$a0.337$$b2020 000089712 593__ $$aAgronomy and Crop Science$$c2020$$dQ3 000089712 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089712 700__ $$aIbáñez-Escriche, N. 000089712 700__ $$aNoguera, J.L. 000089712 700__ $$aCasellas, J. 000089712 700__ $$aMartín de Hijas-Villalba, M. 000089712 700__ $$aGracia-Santana, M.J. 000089712 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza 000089712 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000089712 773__ $$g18, 1 (2020), e0401 [9 pp]$$pSpan. j. agric. res.$$tSpanish Journal of Agricultural Research$$x1695-971X 000089712 8564_ $$s1268923$$uhttps://zaguan.unizar.es/record/89712/files/texto_completo.pdf$$yVersión publicada 000089712 8564_ $$s1697$$uhttps://zaguan.unizar.es/record/89712/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089712 909CO $$ooai:zaguan.unizar.es:89712$$particulos$$pdriver 000089712 951__ $$a2021-09-02-08:55:10 000089712 980__ $$aARTICLE