000089742 001__ 89742 000089742 005__ 20210902121801.0 000089742 0247_ $$2doi$$a10.3390/ijerph17103742 000089742 0248_ $$2sideral$$a118156 000089742 037__ $$aART-2020-118156 000089742 041__ $$aeng 000089742 100__ $$aMoreno-Juste, A. 000089742 245__ $$aInitial therapy, regimen change, and persistence in a spanish cohort of newly treated type 2 diabetes patients: A retrospective, observational study using real-world data 000089742 260__ $$c2020 000089742 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089742 5203_ $$aThe World Health Organization considers the non-adherence to medication a significant issue with global impact, especially in chronic conditions such as type 2 diabetes. We aim to study antidiabetic treatment initiation, add-on, treatment switching, and medication persistence. We conducted an observational study on 4247 individuals initiating antidiabetic treatment between 2013 and 2014 in the EpiChron Cohort (Spain). We used Cox regression models to estimate the likelihood of non-persistence after a one-year follow-up, expressed as hazard ratios (HRs). Metformin was the most frequently used first-line antidiabetic (80% of cases); combination treatment was the second most common treatment in adults aged 40–79 years, while dipeptidyl peptidase-4 inhibitors were the second most common in individuals in their 80s and over, and in patients with renal disease. Individuals initiated on metformin were less likely to present addition and switching events compared with any other antidiabetic. Almost 70% of individuals initiated on monotherapy were persistent. Subjects aged 40 and over (HR 0.53–0.63), living in rural (HR 0.79) or more deprived areas (HR 0.77–0.82), or receiving polypharmacy (HR 0.84), were less likely to show discontinuation. Our findings could help identify the population at risk of discontinuation, and offer them closer monitoring for proper integrated management to improve prognosis and health outcomes. 000089742 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-20R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/EUR/INTERREG-V-POCTEFA-2014-2020 000089742 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089742 590__ $$a3.39$$b2020 000089742 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b41 / 176 = 0.233$$c2020$$dQ1$$eT1 000089742 591__ $$aENVIRONMENTAL SCIENCES$$b118 / 273 = 0.432$$c2020$$dQ2$$eT2 000089742 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b68 / 203 = 0.335$$c2020$$dQ2$$eT2 000089742 592__ $$a0.747$$b2020 000089742 593__ $$aHealth, Toxicology and Mutagenesis$$c2020$$dQ2 000089742 593__ $$aPublic Health, Environmental and Occupational Health$$c2020$$dQ2 000089742 593__ $$aPollution$$c2020$$dQ2 000089742 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089742 700__ $$aPoblador-Plou, B. 000089742 700__ $$aAza-Pascual-Salcedo, M. 000089742 700__ $$aGonzález-Rubio, F. 000089742 700__ $$0(orcid)0000-0002-7194-8275$$aMalo, S.$$uUniversidad de Zaragoza 000089742 700__ $$0(orcid)0000-0002-4859-9054$$aLibrero López, J. 000089742 700__ $$aPico-Soler, V. 000089742 700__ $$aGimenez Labrador, E. 000089742 700__ $$aMucherino, S. 000089742 700__ $$aOrlando, V. 000089742 700__ $$aMenditto, E. 000089742 700__ $$0(orcid)0000-0002-5704-6056$$aPrados-Torres, A. 000089742 700__ $$aGimeno-Miguel, A. 000089742 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000089742 773__ $$g17, 10 (2020), 3742 [16 pp]$$pInt. j. environ. res. public health$$tInternational Journal of Environmental Research and Public Health$$x1661-7827 000089742 8564_ $$s613930$$uhttps://zaguan.unizar.es/record/89742/files/texto_completo.pdf$$yVersión publicada 000089742 8564_ $$s497475$$uhttps://zaguan.unizar.es/record/89742/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089742 909CO $$ooai:zaguan.unizar.es:89742$$particulos$$pdriver 000089742 951__ $$a2021-09-02-09:55:21 000089742 980__ $$aARTICLE