000089818 001__ 89818
000089818 005__ 20230914083253.0
000089818 0247_ $$2doi$$a10.3390/brainsci10050265
000089818 0248_ $$2sideral$$a118166
000089818 037__ $$aART-2020-118166
000089818 041__ $$aeng
000089818 100__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza
000089818 245__ $$aAnxiety and risk of vascular dementia in an elderly community sample: The role of sex
000089818 260__ $$c2020
000089818 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089818 5203_ $$aBackground: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort.
Methods: A random sample of 4057 dementia-free community participants aged 55 or older, from the longitudinal, community-based Zaragoza Dementia and Depression Project (ZARADEMP) study were followed for 4.5 years. Geriatric Mental State B (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) was used for the assessment and diagnosis of anxiety, and a panel of research psychiatrists diagnosed the incident cases of VaD according to DSM-IV (Diagnostic and Statistical Manual of mental disordes). Multivariate survival analysis with competing risk regression model was performed.
Results: In men, the incidence rate of VaD was significantly higher among anxiety subjects compared with non-anxiety subjects (incidence rate ratio (IRR) (95% confidence interval (CI)): 3.24 (1.13–9.35); p = 0.029), and no difference was observed in women (IRR (95%CI): 0.68 (0.19– 2.23); p = 0.168). In the multivariate model, for men, cases of anxiety had 2.6-fold higher risk of VaD (subdistribution hazard ratio (SHR): 2.61; 95%CI: 0.88–7.74) when all potential confounding factors were controlled, with no statistical significance (p = 0.084), but a clinically relevant effect (Cohen’s d: 0.74). No association was found in women.
Conclusions: In men, but not in women, risk of VaD was higher among individuals with anxiety, with a clinically relevant effect. Potential anxiety-related preventive interventions for VaD might be tailored to men and women separately.
000089818 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000089818 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089818 590__ $$a3.394$$b2020
000089818 591__ $$aNEUROSCIENCES$$b157 / 273 = 0.575$$c2020$$dQ3$$eT2
000089818 592__ $$a0.921$$b2020
000089818 593__ $$aNeuroscience (miscellaneous)$$c2020$$dQ3
000089818 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089818 700__ $$aVillagrasa, B.
000089818 700__ $$0(orcid)0000-0002-3360-7015$$aLopez-Anton, R.$$uUniversidad de Zaragoza
000089818 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Cámara, C.$$uUniversidad de Zaragoza
000089818 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000089818 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000089818 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000089818 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000089818 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000089818 773__ $$g10, 5 (2020), 265 [11 pp]$$pBrain sci.$$tBrain Sciences$$x2076-3425
000089818 8564_ $$s448501$$uhttps://zaguan.unizar.es/record/89818/files/texto_completo.pdf$$yVersión publicada
000089818 8564_ $$s516373$$uhttps://zaguan.unizar.es/record/89818/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089818 909CO $$ooai:zaguan.unizar.es:89818$$particulos$$pdriver
000089818 951__ $$a2023-09-13-10:51:29
000089818 980__ $$aARTICLE