89818 20230914083253.0 doi 10.3390/brainsci10050265 sideral 118166 ART-2020-118166 eng Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Anxiety and risk of vascular dementia in an elderly community sample: The role of sex 2020 Access copy available to the general public Unrestricted Background: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort. Methods: A random sample of 4057 dementia-free community participants aged 55 or older, from the longitudinal, community-based Zaragoza Dementia and Depression Project (ZARADEMP) study were followed for 4.5 years. Geriatric Mental State B (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) was used for the assessment and diagnosis of anxiety, and a panel of research psychiatrists diagnosed the incident cases of VaD according to DSM-IV (Diagnostic and Statistical Manual of mental disordes). Multivariate survival analysis with competing risk regression model was performed. Results: In men, the incidence rate of VaD was significantly higher among anxiety subjects compared with non-anxiety subjects (incidence rate ratio (IRR) (95% confidence interval (CI)): 3.24 (1.13–9.35); p = 0.029), and no difference was observed in women (IRR (95%CI): 0.68 (0.19– 2.23); p = 0.168). In the multivariate model, for men, cases of anxiety had 2.6-fold higher risk of VaD (subdistribution hazard ratio (SHR): 2.61; 95%CI: 0.88–7.74) when all potential confounding factors were controlled, with no statistical significance (p = 0.084), but a clinically relevant effect (Cohen’s d: 0.74). No association was found in women. Conclusions: In men, but not in women, risk of VaD was higher among individuals with anxiety, with a clinically relevant effect. Potential anxiety-related preventive interventions for VaD might be tailored to men and women separately. info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.394 2020 NEUROSCIENCES 157 / 273 = 0.575 2020 Q3 T2 0.921 2020 Neuroscience (miscellaneous) 2020 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Villagrasa, B. Lopez-Anton, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 De la Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Lobo, A. Universidad de Zaragoza (orcid)0000-0002-9098-655X 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 10, 5 (2020), 265 [11 pp] Brain sci. Brain Sciences 2076-3425 448501 http://zaguan.unizar.es/record/89818/files/texto_completo.pdf Versión publicada 516373 http://zaguan.unizar.es/record/89818/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89818 articulos driver 2023-09-13-10:51:29 ARTICLE