000089846 001__ 89846 000089846 005__ 20210902121643.0 000089846 0247_ $$2doi$$a10.1371/journal.pone.0230336 000089846 0248_ $$2sideral$$a117961 000089846 037__ $$aART-2020-117961 000089846 041__ $$aeng 000089846 100__ $$aLaviano, E. 000089846 245__ $$aAssociation between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital 000089846 260__ $$c2020 000089846 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089846 5203_ $$aIntroduction Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients. Methods Participants in this prospective analytical observational study were patients who underwent hepatobiliary surgery in a tertiary hospital in Aragon, Spain, between February 2018 and March 2019. Vitamin D concentrations were measured at admission and all nosocomial infections during hospitalization and after discharge were recorded. Results The mean 25-hydroxyvitamin D concentration of the study population (n = 301) was 38.56 nmol/L, which corresponds to vitamin D deficiency. Higher vitamin D concentrations were associated with a decreased likelihood of developing a HAI in general (p = 0.014), and in particularly surgical site infection (p = 0.026). The risk of HAI decreased by 34% with each 26.2-nmol/L increase in serum vitamin D levels. Conclusions Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients. 000089846 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000089846 590__ $$a3.24$$b2020 000089846 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2 000089846 592__ $$a0.99$$b2020 000089846 593__ $$aMultidisciplinary$$c2020$$dQ1 000089846 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089846 700__ $$aSanchez Rubio, M. 000089846 700__ $$aGonzález-Nicolás, M.T. 000089846 700__ $$aPalacian, M.P. 000089846 700__ $$aLópez, J. 000089846 700__ $$0(orcid)0000-0001-8034-3617$$aGilaberte, Y.$$uUniversidad de Zaragoza 000089846 700__ $$aCalmarza, P. 000089846 700__ $$0(orcid)0000-0001-7294-245X$$aRezusta, A.$$uUniversidad de Zaragoza 000089846 700__ $$0(orcid)0000-0003-4712-9891$$aSerrablo, A.$$uUniversidad de Zaragoza 000089846 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología 000089846 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía 000089846 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología 000089846 773__ $$g15, 3 (2020), e0230336 [12 pp]$$pPLoS One$$tPloS one$$x1932-6203 000089846 8564_ $$s428691$$uhttps://zaguan.unizar.es/record/89846/files/texto_completo.pdf$$yVersión publicada 000089846 8564_ $$s411015$$uhttps://zaguan.unizar.es/record/89846/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089846 909CO $$ooai:zaguan.unizar.es:89846$$particulos$$pdriver 000089846 951__ $$a2021-09-02-09:01:53 000089846 980__ $$aARTICLE