000089866 001__ 89866
000089866 005__ 20210902121713.0
000089866 0247_ $$2doi$$a10.1038/s41598-020-64031-2
000089866 0248_ $$2sideral$$a117705
000089866 037__ $$aART-2020-117705
000089866 041__ $$aeng
000089866 100__ $$aNagrani, R.
000089866 245__ $$aCommon genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis
000089866 260__ $$c2020
000089866 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089866 5203_ $$aAs the prevalence of metabolic syndrome (MetS) in children and young adults is increasing, a better understanding of genetics that underlie MetS will provide critical insights into the origin of the disease. We examined associations of common genetic variants and repeated MetS score from early childhood to adolescence in a pan-European, prospective IDEFICS/I.Family cohort study with baseline survey and follow-up examinations after two and six years. We tested associations in 3067 children using a linear mixed model and confirmed the results with meta-analysis of identified SNPs. With a stringent Bonferroni adjustment for multiple comparisons we obtained significant associations(p < 1.4 × 10-4) for 5 SNPs, which were in high LD (r2 > 0.85) in the 16q12.2 non-coding intronic chromosomal region of FTO gene with strongest association observed for rs8050136 (effect size(ß) = 0.31, pWald = 1.52 × 10-5). We also observed a strong association of rs708272 in CETP with increased HDL (p = 5.63 × 10-40) and decreased TRG (p = 9.60 × 10-5) levels. These findings along with meta-analysis advance etiologic understanding of childhood MetS, highlighting that genetic predisposition to MetS is largely driven by genes of obesity and lipid metabolism. Inclusion of the associated genetic variants in polygenic scores for MetS may prove to be fundamental for identifying children and subsequently adults of the high-risk group to allow earlier targeted interventions.
000089866 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181$$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY
000089866 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089866 590__ $$a4.379$$b2020
000089866 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 73 = 0.233$$c2020$$dQ1$$eT1
000089866 592__ $$a1.24$$b2020
000089866 593__ $$aMultidisciplinary$$c2020$$dQ1
000089866 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089866 700__ $$aForaita, R.
000089866 700__ $$aGianfagna, F.
000089866 700__ $$aIacoviello, L.
000089866 700__ $$aMarild, S.
000089866 700__ $$aMichels, N.
000089866 700__ $$aMolnár, D.
000089866 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.$$uUniversidad de Zaragoza
000089866 700__ $$aRusso, P.
000089866 700__ $$aVeidebaum, T.
000089866 700__ $$aAhrens, W.
000089866 700__ $$aMarron, M.
000089866 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000089866 773__ $$g10, 1 (2020), 7189 [14 pp.]$$pSci. rep.$$tScientific Reports$$x2045-2322
000089866 8564_ $$s3241132$$uhttps://zaguan.unizar.es/record/89866/files/texto_completo.pdf$$yVersión publicada
000089866 8564_ $$s147263$$uhttps://zaguan.unizar.es/record/89866/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089866 909CO $$ooai:zaguan.unizar.es:89866$$particulos$$pdriver
000089866 951__ $$a2021-09-02-09:21:59
000089866 980__ $$aARTICLE