000089917 001__ 89917
000089917 005__ 20230526092850.0
000089917 0247_ $$2doi$$a10.1371/journal.pone.0233454
000089917 0248_ $$2sideral$$a118164
000089917 037__ $$aART-2020-118164
000089917 041__ $$aeng
000089917 100__ $$aNuggerud-Galeas, S.
000089917 245__ $$aAnalysis of depressive episodes, their recurrence and pharmacologic treatment in primary care patients: A retrospective descriptive study
000089917 260__ $$c2020
000089917 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089917 5203_ $$aBackground: Depression is one of the most prevalent health problems, frequently being a medium- and long-term condition, with a high comorbidity rate and with frequent relapses and recurrences. Although numerous studies have compared the effectiveness of specific antidepressant therapy drugs and have assessed relapses, scientific evidence on the relationship between pharmacologic treatments and recurrence is scarce. The objective of this study is to describe depressive episodes in a primary care patient cohort, the percentage of depression recurrences and the administered pharmacologic treatment, from a naturalistic perspective.
Methods: Retrospective descriptive study. 957 subjects were included. The dependent variable was a depression diagnosis and independent variables were: gender, age at time of data collection; age of onset, first-episode treatment, number of recurrences, age at recurrences, treatment prescribed for recurrences using therapeutic groups categorization.
Results: Recurrences are frequent, affecting more than 40% of the population. In the first episode, 13.69% of the patients were not prescribed pharmacological treatment, but this percentage decreased over the following depression episodes. 80.9% of the patients who did not receive drug treatment in the first depression episode did not experience subsequent episodes. Monotherapy, and specifically, SSRIs were the most frequently prescribed treatment option for all depressive episodes. Regards the combined pharmacologic treatment, the most frequent drug combinations were SSRIs and benzodiazepines. Limitations In order to increase the power of results, the statistical analysis was performed using therapeutic groups categorization, not individually analyzing each drug and dose.
Conclusions: Depressive episode recurrence is frequent in primary care patients. Further studies having a prospective design are needed in order to expand on this issue.
000089917 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089917 590__ $$a3.24$$b2020
000089917 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2
000089917 592__ $$a0.99$$b2020
000089917 593__ $$aMultidisciplinary$$c2020$$dQ1
000089917 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089917 700__ $$aSaenz Benito Suescun, L.
000089917 700__ $$aBerenguer Torrijo, N.
000089917 700__ $$aSaenz Benito Suescun, A.
000089917 700__ $$0(orcid)0000-0003-2683-7346$$aAguilar-Latorre, A.
000089917 700__ $$0(orcid)0000-0002-5494-6550$$aMagallon Botaya, R.$$uUniversidad de Zaragoza
000089917 700__ $$0(orcid)0000-0001-6565-9699$$aOlivan Blázquez, B.$$uUniversidad de Zaragoza
000089917 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000089917 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000089917 773__ $$g15, 5 (2020), e0233454 [15 pp]$$pPLoS One$$tPLoS ONE$$x1932-6203
000089917 8564_ $$s547097$$uhttps://zaguan.unizar.es/record/89917/files/texto_completo.pdf$$yVersión publicada
000089917 8564_ $$s423988$$uhttps://zaguan.unizar.es/record/89917/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089917 909CO $$ooai:zaguan.unizar.es:89917$$particulos$$pdriver
000089917 951__ $$a2023-05-26-08:12:40
000089917 980__ $$aARTICLE