89941 20210902121745.0 doi 10.3389/fimmu.2020.00872 sideral 118406 ART-2020-118406 eng Anel, A. Universidad de Zaragoza (orcid)0000-0002-5175-8394 Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application 2020 Access copy available to the general public Unrestricted NK cell activity is impaired in cancer patients, supporting the use of adoptive NK cell therapy, which is becoming a credible immunotherapy for hematological malignancies. This is even more so the case after the presentation of the first clinical study using anti-CD19 NK CAR cells, which showed a good clinical activity in the absence of toxicity. The possibility of targeting solid tumors is being studied by numerous laboratories, but the tumor microenvironment supports immune suppression. Unveiling the molecular and cellular mechanisms explaining this immunosuppression is a major goal. For this special issue, we pointed to several specific subjects, such as the metabolic interactions of NK cells with tumor targets that would regulate their function or novel molecular strategies for generating off-the-shelf NK cell cancer immunotherapies. A total of 10 manuscripts have been accepted for publication, of which five are original research and five are reviews or minireviews. Regarding the original research articles, Alvarez et al. have described the indirect contribution of the PD-1/PD-L1 system to the regulation of NK cell exhaustion using an in vivo murine model. They showed that a PD-1 blockade increased CD8+ T cell activation rates, which competed for IL-2 and resources with NK cells, retarding their activation but also their subsequent exhaustion. Federici et al. developed an exhaustive work characterizing NK-cell derived extracellular vesicles (NKEVs), separating true exosomes from microvesicles... info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.561 2020 IMMUNOLOGY 24 / 162 = 0.148 2020 Q1 T1 2.645 2020 Immunology and Allergy 2020 Q1 Immunology 2020 Q1 info:eu-repo/semantics/other info:eu-repo/semantics/publishedVersion Pardo, J. Universidad de Zaragoza (orcid)0000-0003-0154-0730 Villalba, M. 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 11 (2020), 872 [2 pp] Front. immunol. FRONTIERS IN IMMUNOLOGY 1664-3224 66114 http://zaguan.unizar.es/record/89941/files/texto_completo.pdf Versión publicada 29910 http://zaguan.unizar.es/record/89941/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:89941 articulos driver 2021-09-02-09:46:02 ARTICLE