000094456 001__ 94456
000094456 005__ 20220426091141.0
000094456 0247_ $$2doi$$a10.3390/math8060880
000094456 0248_ $$2sideral$$a118460
000094456 037__ $$aART-2020-118460
000094456 041__ $$aeng
000094456 100__ $$0(orcid)0000-0002-8089-343X$$aBarrio, R.$$uUniversidad de Zaragoza
000094456 245__ $$aBifurcations and Slow-Fast Analysis in a Cardiac Cell Model for Investigation of Early Afterdepolarizations
000094456 260__ $$c2020
000094456 5060_ $$aAccess copy available to the general public$$fUnrestricted
000094456 5203_ $$aIn this study, we teased out the dynamical mechanisms underlying the generation of arrhythmogenic early afterdepolarizations (EADs) in a three-variable model of a mammalian ventricular cell. Based on recently published studies, we consider a 1-fast, 2-slow variable decomposition of the system describing the cellular action potential. We use sweeping techniques, such as the spike-counting method, and bifurcation and continuation methods to identify parametric regions with EADs. We show the existence of isolas of periodic orbits organizing the different EAD patterns and we provide a preliminary classification of our fast-slow decomposition according to the involved dynamical phenomena. This investigation represents a basis for further studies into the organization of EAD patterns in the parameter space and the involved bifurcations.
000094456 536__ $$9info:eu-repo/grantAgreement/ES/UZ/CUD2019-CIE-04$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-096026-B-I00$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/MTM2017-87697-P$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2016-75458-R$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9info:eu-repo/grantAgreement/ES/DGA/LMP124-18$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E24-17R
000094456 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000094456 590__ $$a2.258$$b2020
000094456 591__ $$aMATHEMATICS$$b24 / 330 = 0.073$$c2020$$dQ1$$eT1
000094456 592__ $$a0.495$$b2020
000094456 593__ $$aMathematics (miscellaneous)$$c2020$$dQ2
000094456 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000094456 700__ $$0(orcid)0000-0002-7374-3222$$aMartinez, M.A.$$uUniversidad de Zaragoza
000094456 700__ $$aPerez, L.
000094456 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza
000094456 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000094456 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000094456 773__ $$g8, 6 (2020), 880 [17 pp]$$pMathematics (Basel)$$tMathematics$$x2227-7390
000094456 8564_ $$s5325413$$uhttps://zaguan.unizar.es/record/94456/files/texto_completo.pdf$$yVersión publicada
000094456 8564_ $$s459476$$uhttps://zaguan.unizar.es/record/94456/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000094456 951__ $$a2022-04-26-08:57:15
000094456 980__ $$aARTICLE