doi:10.3390/math8060880engBarrio, R.Martinez, M.A.Perez, L.Pueyo, E.Bifurcations and Slow-Fast Analysis in a Cardiac Cell Model for Investigation of Early AfterdepolarizationsART-2020-118460In this study, we teased out the dynamical mechanisms underlying the generation of arrhythmogenic early afterdepolarizations (EADs) in a three-variable model of a mammalian ventricular cell. Based on recently published studies, we consider a 1-fast, 2-slow variable decomposition of the system describing the cellular action potential. We use sweeping techniques, such as the spike-counting method, and bifurcation and continuation methods to identify parametric regions with EADs. We show the existence of isolas of periodic orbits organizing the different EAD patterns and we provide a preliminary classification of our fast-slow decomposition according to the involved dynamical phenomena. This investigation represents a basis for further studies into the organization of EAD patterns in the parameter space and the involved bifurcations.2020http://zaguan.unizar.es/record/9445610.3390/math8060880http://zaguan.unizar.es/record/94456oai:zaguan.unizar.es:94456info:eu-repo/grantAgreement/ES/DGA-FEDER/E24-17Rinfo:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoSinfo:eu-repo/grantAgreement/ES/DGA/LMP124-18info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGEThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGEinfo:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2016-75458-Rinfo:eu-repo/grantAgreement/ES/MINECO-FEDER/MTM2017-87697-Pinfo:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-096026-B-I00info:eu-repo/grantAgreement/ES/UZ/CUD2019-CIE-04Mathematics 8, 6 (2020), 880 [17 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess