94456 20220426091141.0 doi 10.3390/math8060880 sideral 118460 ART-2020-118460 eng Barrio, R. Universidad de Zaragoza (orcid)0000-0002-8089-343X Bifurcations and Slow-Fast Analysis in a Cardiac Cell Model for Investigation of Early Afterdepolarizations 2020 Access copy available to the general public Unrestricted In this study, we teased out the dynamical mechanisms underlying the generation of arrhythmogenic early afterdepolarizations (EADs) in a three-variable model of a mammalian ventricular cell. Based on recently published studies, we consider a 1-fast, 2-slow variable decomposition of the system describing the cellular action potential. We use sweeping techniques, such as the spike-counting method, and bifurcation and continuation methods to identify parametric regions with EADs. We show the existence of isolas of periodic orbits organizing the different EAD patterns and we provide a preliminary classification of our fast-slow decomposition according to the involved dynamical phenomena. This investigation represents a basis for further studies into the organization of EAD patterns in the parameter space and the involved bifurcations. info:eu-repo/grantAgreement/ES/DGA-FEDER/E24-17R info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS info:eu-repo/grantAgreement/ES/DGA/LMP124-18 info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2016-75458-R info:eu-repo/grantAgreement/ES/MINECO-FEDER/MTM2017-87697-P info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-096026-B-I00 info:eu-repo/grantAgreement/ES/UZ/CUD2019-CIE-04 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.258 2020 MATHEMATICS 24 / 330 = 0.073 2020 Q1 T1 0.495 2020 Mathematics (miscellaneous) 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martinez, M.A. Universidad de Zaragoza (orcid)0000-0002-7374-3222 Perez, L. Pueyo, E. Universidad de Zaragoza (orcid)0000-0002-1960-407X 2005 595 Universidad de Zaragoza Dpto. Matemática Aplicada Área Matemática Aplicada 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 8, 6 (2020), 880 [17 pp] Mathematics (Basel) Mathematics 2227-7390 5325413 http://zaguan.unizar.es/record/94456/files/texto_completo.pdf Versión publicada 459476 http://zaguan.unizar.es/record/94456/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:94456 articulos driver 2022-04-26-08:57:15 ARTICLE