000094527 001__ 94527
000094527 005__ 20210902121754.0
000094527 0247_ $$2doi$$a10.1038/s41586-020-2338-1
000094527 0248_ $$2sideral$$a118756
000094527 037__ $$aART-2020-118756
000094527 041__ $$aeng
000094527 100__ $$aNcd Risk Factor Collaboration (ncd-Risc)
000094527 245__ $$aRepositioning of the global epicentre of non-optimal cholesterol
000094527 260__ $$c2020
000094527 5060_ $$aAccess copy available to the general public$$fUnrestricted
000094527 5203_ $$aHigh blood cholesterol is typically considered a feature of wealthy western countries1, 2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4, 5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1, 127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
000094527 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000094527 590__ $$a49.962$$b2020
000094527 591__ $$aMULTIDISCIPLINARY SCIENCES$$b1 / 73 = 0.014$$c2020$$dQ1$$eT1
000094527 592__ $$a15.993$$b2020
000094527 593__ $$aMultidisciplinary$$c2020$$dQ1
000094527 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000094527 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno Aznar, Luis Alberto$$uUniversidad de Zaragoza
000094527 700__ $$0(orcid)0000-0002-0303-7912$$aSantaliestra Pasías, Alba María$$uUniversidad de Zaragoza
000094527 700__ $$a[et al.]
000094527 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000094527 773__ $$g582, 7810 (2020), 73-77$$pNature$$tNature$$x0028-0836
000094527 8564_ $$s13824787$$uhttps://zaguan.unizar.es/record/94527/files/texto_completo.pdf$$yVersión publicada
000094527 8564_ $$s32606$$uhttps://zaguan.unizar.es/record/94527/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000094527 909CO $$ooai:zaguan.unizar.es:94527$$particulos$$pdriver
000094527 951__ $$a2021-09-02-09:50:54
000094527 980__ $$aARTICLE