95052 20210902121808.0 doi 10.3390/ijms21165779 sideral 119002 ART-2020-119002 eng Guijarro, Isabel M. Universidad de Zaragoza (orcid)0000-0001-9773-7460 Neuroimmune Response in Natural Preclinical Scrapie after Dexamethasone Treatment 2020 Access copy available to the general public Unrestricted A recently published report on chronic dexamethasone treatment for natural scrapie supported the hypothesis of the potential failure of astroglia in the advanced stage of disease. Herein, we aimed to extend the aforementioned study on the effect of this anti-inflammatory therapy to the initial phase of scrapie, with the aim of elucidating the natural neuroinflammatory process occurring in this neurodegenerative disorder. The administration of this glucocorticoid resulted in an outstanding reduction in vacuolation and aberrant protein deposition (nearly null), and an increase in glial activation. Furthermore, evident suppression of IL-1R and IL-6 and the exacerbation of IL-1α, IL-2R, IL-10R and IFNγR were also demonstrated. Consequently, the early stage of the disease is characterized by an intact neuroglial response similar to that of healthy individuals attempting to re-establish homeostasis. A complex network of neuroinflammatory markers is involved from the very early stages of this prion disease, which probably becomes impaired in the more advanced stages. The in vivo animal model used herein provides essential observations on the pathogenesis of natural scrapie, as well as the possibility of establishing neuroglia as potential target cells for anti-inflammatory therapy. info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION info:eu-repo/grantAgreement/ES/MEC/FPU15-03524 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.923 2020 BIOCHEMISTRY & MOLECULAR BIOLOGY 67 / 297 = 0.226 2020 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 49 / 178 = 0.275 2020 Q2 T1 1.455 2020 Catalysis 2020 Q1 Computer Science Applications 2020 Q1 Inorganic Chemistry 2020 Q1 Spectroscopy 2020 Q1 Molecular Biology 2020 Q1 Organic Chemistry 2020 Q1 Physical and Theoretical Chemistry 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Garcés, Moisés (orcid)0000-0001-8385-0219 Marín, Belén Universidad de Zaragoza (orcid)0000-0002-1590-3347 Otero, Alicia Universidad de Zaragoza (orcid)0000-0001-9075-2764 Barrio, Tomás (orcid)0000-0002-7037-6316 Badiola, Juan J. Universidad de Zaragoza (orcid)0000-0002-7173-7216 Monzón, Marta Universidad de Zaragoza (orcid)0000-0002-2787-9671 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 21, 16 (2020), 5779 [17 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 6451324 http://zaguan.unizar.es/record/95052/files/texto_completo.pdf Versión publicada 467702 http://zaguan.unizar.es/record/95052/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95052 articulos driver 2021-09-02-09:59:18 ARTICLE