000095063 001__ 95063
000095063 005__ 20230313141237.0
000095063 0247_ $$2doi$$a10.1038/s41598-020-70213-9
000095063 0248_ $$2sideral$$a118778
000095063 037__ $$aART-2020-118778
000095063 041__ $$aeng
000095063 100__ $$0(orcid)0000-0001-6767-8252$$aLópez-Granero, Caridad$$uUniversidad de Zaragoza
000095063 245__ $$aThe BXD21/TyJ recombinant inbred strain as a model for innate inflammatory response in distinct brain regions
000095063 260__ $$c2020
000095063 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095063 5203_ $$aOxidative stress and inflammatory cytokines affect the human brain, increasing the risk for mood and cognitive disorders. Such risk might be selective to brain-specific regions. Here, we determined whether BXD recombinant inbred (RI) mice strains are more suitable than C57BL/6J mice for the understanding of the relationship between antioxidant response and inflammatory responses. We hypothesized that inflammatory responses could be independent of antioxidant response and be inherent to brain-specific regions. This hypothesis will be addressed by the analyses of mRNA expression. We explored, at 7-months-of-age, the innate activation of proinflammatory cytokines (tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), as well as Kelch-like ECH-associating protein 1 (Keap1), nuclear factor erythroid 2 related factor 2 (Nrf2) and glutathione peroxidase 1 (Gpx1) mRNA in both male and female BXD84/RwwJ RI, BXD21/TyJ RI and control strain (C57BL/6J mice). We report that: (1) The cerebellum is more sensitive to antioxidant response in the BXD21/TyJ RI strain; (2) The cerebellum, hippocampus and striatum show increased levels of cytokines in the BXD21/TyJ RI strain; (3) The BXD RI strain has lower brain weight relative to control strain (C57BL/6 mice). In conclusion, our novel data show the utility of the BXD21/TyJ RI strain mice in offering mechanistic insight into Nrf2’s role in the inflammatory system.
000095063 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S24-17R
000095063 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095063 590__ $$a4.379$$b2020
000095063 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 73 = 0.233$$c2020$$dQ1$$eT1
000095063 592__ $$a1.24$$b2020
000095063 593__ $$aMultidisciplinary$$c2020$$dQ1
000095063 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095063 700__ $$aFerrer, Beatriz
000095063 700__ $$aAntunes dos Santos, Alessandra
000095063 700__ $$0(orcid)0000-0001-9320-1888$$aBarrasa, Ángel$$uUniversidad de Zaragoza
000095063 700__ $$aAscher, Michael
000095063 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000095063 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000095063 773__ $$g10 (2020), 13168 [9 pp.]$$pSci. rep.$$tScientific Reports$$x2045-2322
000095063 8564_ $$s950097$$uhttps://zaguan.unizar.es/record/95063/files/texto_completo.pdf$$yVersión publicada
000095063 8564_ $$s328730$$uhttps://zaguan.unizar.es/record/95063/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095063 909CO $$ooai:zaguan.unizar.es:95063$$particulos$$pdriver
000095063 951__ $$a2023-03-13-13:55:50
000095063 980__ $$aARTICLE