95063 20230313141237.0 doi 10.1038/s41598-020-70213-9 sideral 118778 ART-2020-118778 eng López-Granero, Caridad Universidad de Zaragoza (orcid)0000-0001-6767-8252 The BXD21/TyJ recombinant inbred strain as a model for innate inflammatory response in distinct brain regions 2020 Access copy available to the general public Unrestricted Oxidative stress and inflammatory cytokines affect the human brain, increasing the risk for mood and cognitive disorders. Such risk might be selective to brain-specific regions. Here, we determined whether BXD recombinant inbred (RI) mice strains are more suitable than C57BL/6J mice for the understanding of the relationship between antioxidant response and inflammatory responses. We hypothesized that inflammatory responses could be independent of antioxidant response and be inherent to brain-specific regions. This hypothesis will be addressed by the analyses of mRNA expression. We explored, at 7-months-of-age, the innate activation of proinflammatory cytokines (tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), as well as Kelch-like ECH-associating protein 1 (Keap1), nuclear factor erythroid 2 related factor 2 (Nrf2) and glutathione peroxidase 1 (Gpx1) mRNA in both male and female BXD84/RwwJ RI, BXD21/TyJ RI and control strain (C57BL/6J mice). We report that: (1) The cerebellum is more sensitive to antioxidant response in the BXD21/TyJ RI strain; (2) The cerebellum, hippocampus and striatum show increased levels of cytokines in the BXD21/TyJ RI strain; (3) The BXD RI strain has lower brain weight relative to control strain (C57BL/6 mice). In conclusion, our novel data show the utility of the BXD21/TyJ RI strain mice in offering mechanistic insight into Nrf2’s role in the inflammatory system. info:eu-repo/grantAgreement/ES/DGA/S24-17R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.379 2020 MULTIDISCIPLINARY SCIENCES 17 / 73 = 0.233 2020 Q1 T1 1.24 2020 Multidisciplinary 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ferrer, Beatriz Antunes dos Santos, Alessandra Barrasa, Ángel Universidad de Zaragoza (orcid)0000-0001-9320-1888 Ascher, Michael 4009 740 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Social 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 10 (2020), 13168 [9 pp.] Sci. rep. Scientific Reports 2045-2322 950097 http://zaguan.unizar.es/record/95063/files/texto_completo.pdf Versión publicada 328730 http://zaguan.unizar.es/record/95063/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95063 articulos driver 2023-03-13-13:55:50 ARTICLE