000095078 001__ 95078
000095078 005__ 20230421130008.0
000095078 0247_ $$2doi$$a10.3390/jcm9051368
000095078 0248_ $$2sideral$$a118739
000095078 037__ $$aART-2020-118739
000095078 041__ $$aeng
000095078 100__ $$0(orcid)0000-0002-7297-6104$$aSantabarbara, Javier$$uUniversidad de Zaragoza
000095078 245__ $$aAssociation between anxiety and vascular dementia risk: new evidence and an updated meta-analysis
000095078 260__ $$c2020
000095078 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095078 5203_ $$aThe association between anxiety and vascular dementia (VaD) is unclear. We aimed to reliably estimate the association between anxiety and VaD risk using meta-analysis to pool new results from a large community-based cohort (Zaragoza Dementia and Depression (ZARADEMP) study) and results from previous studies. ZARADEMP participants (n = 4057) free of dementia were followed up on for up to 12 years. Cases and subcases of anxiety were determined at baseline. A panel of four psychiatrists diagnosed incident cases of VaD by consensus. We searched for similar studies published up to October 2019 using PubMed and Web of Science. Observational studies reporting associations between anxiety and VaD risk, and adjusting at least for age, were selected. Odds ratios (ORs) from each study were combined using fixed-effects models. In the ZARADEMP study, the risk of VaD was 1.41 times higher among individuals with anxiety (95% CI: 0.75-2.68) compared with non-cases (p = 0.288). Pooling this result with results from two previous studies yielded an OR of 1.65 (95% CI: 1.07-2.53; p = 0.022). These findings indicate that anxiety is associated with an increased risk of VaD. Taking into account that anxiety is commonly observed in the elderly, treating and preventing it might reduce the prevalence and incidence of VaD. However, whether anxiety is a cause of a prodrome of VaD is still unknown, and future research is needed to clarify this.
000095078 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000095078 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095078 590__ $$a4.241$$b2020
000095078 591__ $$aMEDICINE, GENERAL & INTERNAL$$b39 / 169 = 0.231$$c2020$$dQ1$$eT1
000095078 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000095078 700__ $$aLipnicki, Darren M.
000095078 700__ $$aOlaya, Beatriz
000095078 700__ $$aVillagrasa, Beatriz
000095078 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-Garcia, Patricia$$uUniversidad de Zaragoza
000095078 700__ $$aBueno-Notivol, Juan
000095078 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000095078 700__ $$0(orcid)0000-0002-3360-7015$$aLopez-Anton, Raúl$$uUniversidad de Zaragoza
000095078 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000095078 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000095078 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000095078 773__ $$g9, 5 (2020), 1368 [13 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000095078 8564_ $$s619464$$uhttps://zaguan.unizar.es/record/95078/files/texto_completo.pdf$$yVersión publicada
000095078 8564_ $$s472947$$uhttps://zaguan.unizar.es/record/95078/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095078 951__ $$a2023-04-21-12:41:45
000095078 980__ $$aARTICLE