95314 20260217205445.0 doi 10.3390/cells9061525 sideral 119056 ART-2020-119056 eng Gascón, Marta (orcid)0000-0002-6811-6654 Intratumoral versus Circulating Lymphoid Cells as Predictive Biomarkers in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: Is the Easiest Path the Best One? 2020 Access copy available to the general public Unrestricted The molecular and cell determinants that modulate immune checkpoint (ICI) efficacy in lung cancer are still not well understood. However, there is a necessity to select those patients that will most benefit from these new treatments. Recent studies suggest the presence and/or the relative balance of specific lymphoid cells in the tumor microenvironment (TEM) including the T cell (activated, memory, and regulatory) and NK cell (CD56dim/bright) subsets, and correlate with a better response to ICI. The analyses of these cell subsets in peripheral blood, as a more accessible and homogeneous sample, might facilitate clinical decisions concerning fast prediction of ICI efficacy. Despite recent studies suggesting that lymphoid circulating cells might correlate with ICI efficacy and toxicity, more analyses and investigation are required to confirm if circulating lymphoid cells are a relevant picture of the lung TME and could be instrumental as ICI response biomarkers. This short review is aimed to discuss the recent advances in this fast-growing field. info:eu-repo/grantAgreement/ES/DGA/B29 info:eu-repo/grantAgreement/ES/MINECO/SAF2017-83120-C2-1-R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.6 2020 CELL BIOLOGY 53 / 195 = 0.272 2020 Q2 T1 1.22 2020 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Isla, Dolores Cruellas, Mara Gálvez, Eva M. Universidad de Zaragoza Lastra, Rodrigo Ocáriz, Maitane Paño, José Ramón Universidad de Zaragoza (orcid)0000-0002-9600-8116 Ramírez, Ariel Sesma, Andrea Torres-Ramón, Irene Universidad de Zaragoza (orcid)0000-0003-3387-0558 Yubero, Alfonso Pardo, Julián Universidad de Zaragoza (orcid)0000-0003-0154-0730 Martínez-Lostao, Luis Universidad de Zaragoza (orcid)0000-0003-3043-147X 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 9, 6 (2020), 1525 [16 pp.] Cells Cells 2073-4409 818240 http://zaguan.unizar.es/record/95314/files/texto_completo.pdf Versión publicada 456844 http://zaguan.unizar.es/record/95314/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95314 articulos driver 2026-02-17-20:17:39 ARTICLE