000095316 001__ 95316
000095316 005__ 20220525082808.0
000095316 0247_ $$2doi$$a10.3390/jcm9061705
000095316 0248_ $$2sideral$$a119058
000095316 037__ $$aART-2020-119058
000095316 041__ $$aeng
000095316 100__ $$aAnguita-Ruiz, A
000095316 245__ $$aEvaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty
000095316 260__ $$c2020
000095316 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095316 5203_ $$aPolygenetic risk scores (pGRSs) consisting of adult body mass index (BMI) genetic variants have been widely associated with obesity in children populations. The implication of such obesity pGRSs in the development of cardio-metabolic alterations during childhood as well as their utility for the clinical prediction of pubertal obesity outcomes has been barely investigated otherwise. In the present study, we evaluated the utility of an adult BMI predisposing pGRS for the prediction and pharmacological management of obesity in Spanish children, further investigating its implication in the appearance of cardio-metabolic alterations. For that purpose, we counted on genetics data from three well-characterized children populations (composed of 574, 96 and 124 individuals), following both cross-sectional and longitudinal designs, expanding childhood and puberty. As a result, we demonstrated that the pGRS is strongly associated with childhood BMI Z-Score (B = 1.56, SE = 0.27 andp-value = 1.90 x 10(-8)), and that could be used as a good predictor of obesity longitudinal trajectories during puberty. On the other hand, we showed that the pGRS is not associated with cardio-metabolic comorbidities in children and that certain environmental factors interact with the genetic predisposition to the disease. Finally, according to the results derived from a weight-reduction metformin intervention in children with obesity, we discarded the utility of the pGRS as a pharmacogenetics marker of metformin response.
000095316 536__ $$9info:eu-repo/grantAgreement/ES/MSCBS/EC10-281$$9info:eu-repo/grantAgreement/ES/MSCBS/EC10-243$$9info:eu-repo/grantAgreement/ES/MSCBS/EC10-227$$9info:eu-repo/grantAgreement/ES/MSCBS/EC10-056$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02059$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048
000095316 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095316 590__ $$a4.241$$b2020
000095316 591__ $$aMEDICINE, GENERAL & INTERNAL$$b39 / 169 = 0.231$$c2020$$dQ1$$eT1
000095316 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095316 700__ $$aGonzalez-Gil, EM
000095316 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez, Azahara I.$$uUniversidad de Zaragoza
000095316 700__ $$aLlorente-Cantarero, FJ
000095316 700__ $$aPastor-Villaescusa, B
000095316 700__ $$aAlcala-Fdez, J
000095316 700__ $$aMoreno, LA
000095316 700__ $$aGil, A
000095316 700__ $$aGil-Campos, M
000095316 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000095316 700__ $$aLeis, R
000095316 700__ $$aAguilera, CM
000095316 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000095316 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000095316 773__ $$g9, 6 (2020), 1705 [23 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000095316 8564_ $$s1187585$$uhttps://zaguan.unizar.es/record/95316/files/texto_completo.pdf$$yVersión publicada
000095316 8564_ $$s530434$$uhttps://zaguan.unizar.es/record/95316/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095316 909CO $$ooai:zaguan.unizar.es:95316$$particulos$$pdriver
000095316 951__ $$a2022-05-25-08:26:05
000095316 980__ $$aARTICLE