000095317 001__ 95317
000095317 005__ 20230421130009.0
000095317 0247_ $$2doi$$a10.3390/jcm9061791
000095317 0248_ $$2sideral$$a119059
000095317 037__ $$aART-2020-119059
000095317 041__ $$aeng
000095317 100__ $$0(orcid)0000-0002-7297-6104$$aSantabarbara, Javier$$uUniversidad de Zaragoza
000095317 245__ $$aDoes Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies
000095317 260__ $$c2020
000095317 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095317 5203_ $$aBackground:Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF).Methods:We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF.Results:The meta-analysis included nine prospective cohorts from eight studies, representing 29, 608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06-1.46) and the PAF of dementia due to anxiety was 3.9%.Conclusions:Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.
000095317 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000095317 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095317 590__ $$a4.241$$b2020
000095317 591__ $$aMEDICINE, GENERAL & INTERNAL$$b39 / 169 = 0.231$$c2020$$dQ1$$eT1
000095317 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095317 700__ $$aLipnicki, Darren M.
000095317 700__ $$aOlaya, Beatriz
000095317 700__ $$aVillagrasa, Beatriz
000095317 700__ $$aBueno-Notivol, Juan
000095317 700__ $$aNuez, Lucía
000095317 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, Raúl$$uUniversidad de Zaragoza
000095317 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, Patricia$$uUniversidad de Zaragoza
000095317 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000095317 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000095317 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000095317 773__ $$g9, 6 (2020), 1791 [14 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000095317 8564_ $$s786307$$uhttps://zaguan.unizar.es/record/95317/files/texto_completo.pdf$$yVersión publicada
000095317 8564_ $$s453950$$uhttps://zaguan.unizar.es/record/95317/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095317 951__ $$a2023-04-21-12:42:05
000095317 980__ $$aARTICLE