000095333 001__ 95333
000095333 005__ 20210902121823.0
000095333 0247_ $$2doi$$a10.1038/s41598-020-68076-1
000095333 0248_ $$2sideral$$a119083
000095333 037__ $$aART-2020-119083
000095333 041__ $$aeng
000095333 100__ $$0(orcid)0000-0002-3726-0493$$aAuria-Luna, Fernando
000095333 245__ $$aUltrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies
000095333 260__ $$c2020
000095333 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095333 5203_ $$aA simple approach to synthesize new highly substituted 4H-pyran derivatives is described. Efficient Et3N acts as a readily accessible catalyst of this process performed in pure water and with only a 20 mol% of catalyst loading. The extremely simple operational methodology, short reaction times, clean procedure and excellent product yields render this new approach extremely appealing for the synthesis of 4H-pyrans, as potentially biological scaffolds. Additionally, DNA interaction analysis reveals that 4H-pyran derivatives behave preferably as minor groove binders over major groove or intercalators. Therefore, this is one of the scarce examples where pyrans have resulted to be interesting DNA binders with high binding constants (Kb ranges from 1.53 × 104 M-1 to 2.05 × 106 M-1).
000095333 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097836-J-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC-2018-025872-I$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2017-88091-P$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21
000095333 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095333 590__ $$a4.379$$b2020
000095333 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 73 = 0.233$$c2020$$dQ1$$eT1
000095333 592__ $$a1.24$$b2020
000095333 593__ $$aMultidisciplinary$$c2020$$dQ1
000095333 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095333 700__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa$$uUniversidad de Zaragoza
000095333 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000095333 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción$$uUniversidad de Zaragoza
000095333 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel$$uUniversidad de Zaragoza
000095333 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000095333 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000095333 773__ $$g10, 1 (2020), 11594 [17 pp.]$$pSci. rep.$$tScientific Reports$$x2045-2322
000095333 8564_ $$s1642193$$uhttps://zaguan.unizar.es/record/95333/files/texto_completo.pdf$$yVersión publicada
000095333 8564_ $$s253504$$uhttps://zaguan.unizar.es/record/95333/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095333 909CO $$ooai:zaguan.unizar.es:95333$$particulos$$pdriver
000095333 951__ $$a2021-09-02-10:09:36
000095333 980__ $$aARTICLE