95333 20210902121823.0 doi 10.1038/s41598-020-68076-1 sideral 119083 ART-2020-119083 eng Auria-Luna, Fernando (orcid)0000-0002-3726-0493 Ultrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies 2020 Access copy available to the general public Unrestricted A simple approach to synthesize new highly substituted 4H-pyran derivatives is described. Efficient Et3N acts as a readily accessible catalyst of this process performed in pure water and with only a 20 mol% of catalyst loading. The extremely simple operational methodology, short reaction times, clean procedure and excellent product yields render this new approach extremely appealing for the synthesis of 4H-pyrans, as potentially biological scaffolds. Additionally, DNA interaction analysis reveals that 4H-pyran derivatives behave preferably as minor groove binders over major groove or intercalators. Therefore, this is one of the scarce examples where pyrans have resulted to be interesting DNA binders with high binding constants (Kb ranges from 1.53 × 104 M-1 to 2.05 × 106 M-1). info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097836-J-I00 info:eu-repo/grantAgreement/ES/MICINN/RYC-2018-025872-I info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2017-88091-P info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.379 2020 MULTIDISCIPLINARY SCIENCES 17 / 73 = 0.233 2020 Q1 T1 1.24 2020 Multidisciplinary 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fernández-Moreira, Vanesa Universidad de Zaragoza (orcid)0000-0002-1218-7218 Marqués-López, Eugenia Universidad de Zaragoza (orcid)0000-0001-6832-8983 Gimeno, M. Concepción Universidad de Zaragoza (orcid)0000-0003-0553-0695 Pérez Herrera, Raquel Universidad de Zaragoza (orcid)0000-0002-5244-9569 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 10, 1 (2020), 11594 [17 pp.] Sci. rep. Scientific Reports 2045-2322 1642193 http://zaguan.unizar.es/record/95333/files/texto_completo.pdf Versión publicada 253504 http://zaguan.unizar.es/record/95333/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95333 articulos driver 2021-09-02-10:09:36 ARTICLE