95346 20210902121829.0 doi 10.1038/s41467-020-17302-5 sideral 119090 ART-2020-119090 eng Gordon, S.P. Gradual polyploid genome evolution revealed by pan-genomic analysis of Brachypodium hybridum and its diploid progenitors 2020 Access copy available to the general public Unrestricted Our understanding of polyploid genome evolution is constrained because we cannot know the exact founders of a particular polyploid. To differentiate between founder effects and post polyploidization evolution, we use a pan-genomic approach to study the allotetraploid Brachypodium hybridum and its diploid progenitors. Comparative analysis suggests that most B. hybridum whole gene presence/absence variation is part of the standing variation in its diploid progenitors. Analysis of nuclear single nucleotide variants, plastomes and k-mers associated with retrotransposons reveals two independent origins for B. hybridum, ~1.4 and ~0.14 million years ago. Examination of gene expression in the younger B. hybridum lineage reveals no bias in overall subgenome expression. Our results are consistent with a gradual accumulation of genomic changes after polyploidization and a lack of subgenome expression dominance. Significantly, if we did not use a pan-genomic approach, we would grossly overestimate the number of genomic changes attributable to post polyploidization evolution. info:eu-repo/grantAgreement/ES/DGA/A01 info:eu-repo/grantAgreement/ES/MINECO/CGL2016-79790-P info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 14.919 2020 MULTIDISCIPLINARY SCIENCES 4 / 73 = 0.055 2020 Q1 T1 5.559 2020 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2020 Q1 Physics and Astronomy (miscellaneous) 2020 Q1 Chemistry (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Contreras-Moreira, B. Universidad de Zaragoza (orcid)0000-0002-5462-907X Levy, J.J. Djamei, A. Czedik-Eysenberg, A. Tartaglio, V.S. Session, A. Martin, J. Cartwright, A. Katz, A. Singan, V.R. Goltsman, E. Barry, K. Dinh-Thi, V.H. Chalhoub, B. Diaz-Perez, A. Sancho, R. (orcid)0000-0002-4845-4242 Lusinska, J. Wolny, E. Nibau, C. Doonan, J.H. Mur, L.A.J. Plott, C. Jenkins, J. Hazen, S.P. Lee, S.J. Shu, S. Goodstein, D. Rokhsar, D. Schmutz, J. Hasterok, R. Catalan, P. Universidad de Zaragoza (orcid)0000-0001-7793-5259 Vogel, J.P. 5011 063 Universidad de Zaragoza Dpto. CC.Agrar.y Medio Natural Área Botánica 11, 1 (2020), 3670 [16 pp] NATURE COMMUNICATIONS Nature Communications 2041-1723 2989495 http://zaguan.unizar.es/record/95346/files/texto_completo.pdf Versión publicada 70016 http://zaguan.unizar.es/record/95346/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95346 articulos driver 2021-09-02-10:13:52 ARTICLE