000095368 001__ 95368
000095368 005__ 20220525082808.0
000095368 0247_ $$2doi$$a10.3390/antiox9070618
000095368 0248_ $$2sideral$$a119168
000095368 037__ $$aART-2020-119168
000095368 041__ $$aeng
000095368 100__ $$0(orcid)0000-0002-3850-8235$$aRupérez, Azahara I.$$uUniversidad de Zaragoza
000095368 245__ $$aAntioxidants and oxidative stress in children: Influence of puberty and metabolically unhealthy status
000095368 260__ $$c2020
000095368 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095368 5203_ $$aOxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.
000095368 536__ $$9info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30038$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-012$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02059$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-01425$$9info:eu-repo/grantAgreement/ES/ISCIII/PI051968$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043
000095368 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095368 590__ $$a6.312$$b2020
000095368 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b60 / 297 = 0.202$$c2020$$dQ1$$eT1
000095368 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b11 / 144 = 0.076$$c2020$$dQ1$$eT1
000095368 591__ $$aCHEMISTRY, MEDICINAL$$b6 / 63 = 0.095$$c2020$$dQ1$$eT1
000095368 592__ $$a1.066$$b2020
000095368 593__ $$aBiochemistry$$c2020$$dQ2
000095368 593__ $$aCell Biology$$c2020$$dQ2
000095368 593__ $$aPhysiology$$c2020$$dQ2
000095368 593__ $$aMolecular Biology$$c2020$$dQ2
000095368 593__ $$aClinical Biochemistry$$c2020$$dQ2
000095368 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095368 700__ $$aMesa, María D.
000095368 700__ $$aAnguita-Ruiz, Augusto
000095368 700__ $$0(orcid)0000-0003-2005-8229$$aGonzález-Gil, Esther M.
000095368 700__ $$aVázquez-Cobela, Rocío
000095368 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000095368 700__ $$aGil, Ángel
000095368 700__ $$aGil-Campos, Mercedes
000095368 700__ $$aLeis, Rosaura
000095368 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000095368 700__ $$aAguilera, Concepción M.
000095368 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000095368 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000095368 773__ $$g9, 7 (2020), 618 [19 pp.]$$pAntioxidants$$tAntioxidants$$x2076-3921
000095368 8564_ $$s576910$$uhttps://zaguan.unizar.es/record/95368/files/texto_completo.pdf$$yVersión publicada
000095368 8564_ $$s509754$$uhttps://zaguan.unizar.es/record/95368/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095368 909CO $$ooai:zaguan.unizar.es:95368$$particulos$$pdriver
000095368 951__ $$a2022-05-25-08:26:16
000095368 980__ $$aARTICLE