000095410 001__ 95410 000095410 005__ 20210902121748.0 000095410 0247_ $$2doi$$a10.1371/journal.pone.0235148 000095410 0248_ $$2sideral$$a118929 000095410 037__ $$aART-2020-118929 000095410 041__ $$aeng 000095410 100__ $$aLozano-Hernandez, CM 000095410 245__ $$aSocial support, social context and nonadherence to treatment in young senior patients with multimorbidity and polypharmacy followed-up in primary care. MULTIPAP Study 000095410 260__ $$c2020 000095410 5060_ $$aAccess copy available to the general public$$fUnrestricted 000095410 5203_ $$aObjective To estimate the prevalence of nonadherence to treatment and its relationship with social support and social context in patients with multimorbidity and polypharmacy followed-up in primary care. Methods This was an observational, descriptive, cross-sectional, multicenter study with an analytical approach. A total of 593 patients between 65-74 years of age with multimorbidity (>= 3 diseases) and polypharmacy (>= 5 drugs) during the last three months and agreed to participate in the MULTIPAP Study. The main variable was adherence (Morisky-Green). The predictors were social support (structural support and functional support (DUFSS)); sociodemographic variables; indicators of urban objective vulnerability; health-related quality of life (EQ-5D-5L-VAS & QALY); and clinical variables. Descriptive, bivariate and multivariate analyses with logistic regression models and robust estimators were performed. Results Four out of ten patients were nonadherent, 47% had not completed primary education, 28.7% had an income <= 1050 euro/month, 35% reported four or more IUVs, and the average perceived health-related quality of life (HRQOL) EQ-5D-5L-VAS was 65.5. The items that measure functional support, with significantly different means between nonadherent and adherent patients were receiving love and affection (-0.23; 95%CI: -0.40;-0.06), help when ill (-0.25; 95%CI: -0.42;-0.08), useful advice (-0.20; 95%CI: -0.37;-0.02), social invitations (-0.22; 95%CI:-0.44;-0.01), and recognition (-0.29; 95%CI:-0.50;-0.08). Factors associated with nonadherence were belonging to the medium vs. low tertile of functional support (0.62; 95%CI: 0.42;0.94), reporting less than four IUVs (0.69; 95%CI: 0.46;1.02) and higher HRQOL perception (0.98; 95%CI: 0.98;0.99). Conclusions Among patients 65-74 years of age with multimorbidity and polypharmacy, lower functional support was related to nonadherence to treatment. The nonadherence decreased in those patients with higher functional support, lower urban vulnerability and higher perceived health status according to the visual analog scale of health-related quality of life. 000095410 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00276$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00572$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00996 000095410 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000095410 590__ $$a3.24$$b2020 000095410 591__ $$aMULTIDISCIPLINARY SCIENCES$$b26 / 73 = 0.356$$c2020$$dQ2$$eT2 000095410 592__ $$a0.99$$b2020 000095410 593__ $$aMultidisciplinary$$c2020$$dQ1 000095410 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000095410 700__ $$aLopez-Rodriguez, JA 000095410 700__ $$aLeiva-Fernandez, F 000095410 700__ $$aCalderon-Larranaga, A 000095410 700__ $$aBarrio-Cortes, J 000095410 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliu, LA$$uUniversidad de Zaragoza 000095410 700__ $$aPoblador-Plou, B 000095410 700__ $$adel Cura-Gonzalez, I 000095410 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000095410 773__ $$g15, 6 (2020), 0235148 [15 pp]$$pPLoS One$$tPloS one$$x1932-6203 000095410 8564_ $$s631799$$uhttps://zaguan.unizar.es/record/95410/files/texto_completo.pdf$$yVersión publicada 000095410 8564_ $$s469705$$uhttps://zaguan.unizar.es/record/95410/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000095410 909CO $$ooai:zaguan.unizar.es:95410$$particulos$$pdriver 000095410 951__ $$a2021-09-02-09:47:37 000095410 980__ $$aARTICLE