doi:10.1002/1873-3468.13610engGuio, JorgeSarasa-Buisán, CristinaVelázquez-Campoy, AdriánBes, María TeresaFillat, María FPeleato, María LuisaSevilla, Emma2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120ART-2020-1152782-oxoglutarate (2-OG) is a central metabolite that acts as a signaling molecule informing about the status of the carbon/nitrogen balance of the cell. In recent years, some transcriptional regulators and even two-component systems have been described as 2-OG sensors. In the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120, two master regulators, NtcA and FurA, are deeply involved in the regulation of nitrogen metabolism. Both of them show a complex intertwined regulatory circuit to achieve a suitable regulation of nitrogen fixation. In this work, 2-OG is found to bind FurA, modulating the specific binding of FurA to the ntcA promoter. This study provides evidence of a new additional control point in the complex network controlled by the NtcA and FurA proteins.2020http://zaguan.unizar.es/record/9543910.1002/1873-3468.13610http://zaguan.unizar.es/record/95439oai:zaguan.unizar.es:95439info:eu-repo/grantAgreement/ES/DGA/E35-17Rinfo:eu-repo/grantAgreement/ES/MINECO/BFU2016-77671-PFEBS Letters 594, 2 (2020), 278-289All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess