95439 20260119151007.0 doi 10.1002/1873-3468.13610 sideral 115278 ART-2020-115278 eng Guio, Jorge Universidad de Zaragoza (orcid)0000-0002-0474-255X 2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120 2020 Access copy available to the general public Unrestricted 2-oxoglutarate (2-OG) is a central metabolite that acts as a signaling molecule informing about the status of the carbon/nitrogen balance of the cell. In recent years, some transcriptional regulators and even two-component systems have been described as 2-OG sensors. In the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120, two master regulators, NtcA and FurA, are deeply involved in the regulation of nitrogen metabolism. Both of them show a complex intertwined regulatory circuit to achieve a suitable regulation of nitrogen fixation. In this work, 2-OG is found to bind FurA, modulating the specific binding of FurA to the ntcA promoter. This study provides evidence of a new additional control point in the complex network controlled by the NtcA and FurA proteins. info:eu-repo/grantAgreement/ES/DGA/E35-17R info:eu-repo/grantAgreement/ES/MINECO/BFU2016-77671-P info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.124 2020 BIOPHYSICS 17 / 71 = 0.239 2020 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 131 / 296 = 0.443 2020 Q2 T2 CELL BIOLOGY 114 / 195 = 0.585 2020 Q3 T2 1.593 2020 Biochemistry 2020 Q1 Biophysics 2020 Q1 Structural Biology 2020 Q1 Genetics 2020 Q1 Molecular Biology 2020 Q1 Cell Biology 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Sarasa-Buisán, Cristina Universidad de Zaragoza (orcid)0000-0002-1960-2672 Velázquez-Campoy, Adrián Universidad de Zaragoza (orcid)0000-0001-5702-4538 Bes, María Teresa Universidad de Zaragoza (orcid)0000-0002-8181-2689 Fillat, María F Universidad de Zaragoza (orcid)0000-0001-8644-4574 Peleato, María Luisa Universidad de Zaragoza (orcid)0000-0002-2742-3711 Sevilla, Emma Universidad de Zaragoza (orcid)0000-0001-6435-3540 1002 412 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Fisiología Vegetal 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 594, 2 (2020), 278-289 FEBS lett. FEBS Letters 0014-5793 1475987 http://zaguan.unizar.es/record/95439/files/texto_completo.pdf Postprint 94326 http://zaguan.unizar.es/record/95439/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:95439 articulos driver 2026-01-19-15:09:27 ARTICLE