95456 20230926093530.0 doi 10.1038/s41929-019-0333-4 sideral 114071 ART-2019-114071 eng Sancho-Albero, María Universidad de Zaragoza (orcid)0000-0001-8762-5457 Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis 2019 Access copy available to the general public Unrestricted The transformational impact of bioorthogonal chemistries has inspired new strategies for the in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts have played a prominent role in the growing subfield of bioorthogonal catalysis by producing xenobiotics and uncaging biomolecules in living systems. However, delivering catalysts selectively to specific cell types still lags behind catalyst development. Here, we have developed a bioartificial device comprising cancer-derived exosomes that are loaded with Pd catalysts by a method that enables the controlled assembly of Pd nanosheets directly inside the vesicles. This hybrid system mediates Pd-triggered dealkylation reactions in vitro and inside cells, and displays preferential tropism for their progenitor cells. The use of Trojan exosomes to deliver abiotic catalysts into designated cancer cells creates the opportunity for a new targeted therapy modality; that is, exosome-directed catalyst prodrug therapy, whose first steps are presented herein with the cell-specific release of the anticancer drug panobinostat. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/grantAgreement/EC/H2020/658833/EU/Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy/ChemoBOOM This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 658833-ChemoBOOM info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 30.471 2019 CHEMISTRY, PHYSICAL 2 / 159 = 0.013 2019 Q1 T1 11.104 2019 Biochemistry 2019 Q1 Process Chemistry and Technology 2019 Q1 Catalysis 2019 Q1 Bioengineering 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Rubio-Ruiz, Belén Pérez-López, Ana M. Sebastián, Víctor Universidad de Zaragoza (orcid)0000-0002-6873-5244 Martín-Duque, Pilar (orcid)0000-0003-4160-9720 Arruebo, Manuel Universidad de Zaragoza (orcid)0000-0003-3165-0156 Santamaría, Jesús Universidad de Zaragoza (orcid)0000-0002-8701-9745 Unciti-Broceta, Asier 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 2, 10 (2019), 864–872 Nat. catal. Nature Catalysis 2520-1158 1895626 http://zaguan.unizar.es/record/95456/files/texto_completo.pdf Postprint 446758 http://zaguan.unizar.es/record/95456/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:95456 articulos driver 2023-09-26-09:29:49 ARTICLE