000095465 001__ 95465 000095465 005__ 20230914083248.0 000095465 0247_ $$2doi$$a10.3390/plants9091250 000095465 0248_ $$2sideral$$a119777 000095465 037__ $$aART-2020-119777 000095465 041__ $$aeng 000095465 100__ $$0(orcid)0000-0001-8822-7303$$aAsensio, Esther$$uUniversidad de Zaragoza 000095465 245__ $$aPhenolic compounds content and genetic diversity at population level across the natural distribution range of bearberry (arctostaphylos uva-ursi, ericaceae) in the iberian peninsula 000095465 260__ $$c2020 000095465 5060_ $$aAccess copy available to the general public$$fUnrestricted 000095465 5203_ $$aBearberry (Arctostaphylos uva-ursi) is a medicinal plant traditionally employed for the treatment of urinary tract infections due to high contents of arbutin (hydroquinone β-D-glucoside), which is now mainly used as a natural skin-whitening agent in cosmetics. Bearberry has also been proposed as a natural antioxidant additive due to the high contents of phenolic compounds in leaves. We studied the variation on phenolic compounds in 42 wild populations of bearberry, aiming to elucidate if intrinsic biological, climatic, and/or geographic factors affect phenolic contents across its natural distribution in the Iberian Peninsula. Bearberry leaves were collected during autumn over a three-year period (2014–2016) in populations across a latitude and altitude gradient. Methanolic extracts showed a wide range of variation in total phenols content, and different phenolic profiles regarding arbutin (levels of this major constituent varied from 87 to 232 mg/g dr wt), but also catechin and myricetin contents, which were affected by geographic and climatic factors. Moderate levels of variation on genome size—assessed by flow cytometry—and on two plastid DNA regions were also detected among populations. Genetic and cytogenetic differentiation of populations was weakly but significantly associated to phytochemical diversity. Elite bearberry genotypes with higher antioxidant capacity were subsequently identified. 000095465 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/CGL2017-84297-R 000095465 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000095465 590__ $$a3.935$$b2020 000095465 591__ $$aPLANT SCIENCES$$b47 / 235 = 0.2$$c2020$$dQ1$$eT1 000095465 592__ $$a0.892$$b2020 000095465 593__ $$aEcology$$c2020$$dQ1 000095465 593__ $$aPlant Science$$c2020$$dQ1 000095465 593__ $$aEcology, Evolution, Behavior and Systematics$$c2020$$dQ1 000095465 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000095465 700__ $$aVitales, Daniel 000095465 700__ $$aPérez, Iván 000095465 700__ $$aPeralba, Laia 000095465 700__ $$aViruel, Juan 000095465 700__ $$0(orcid)0000-0001-5180-7339$$aMontaner, Celia$$uUniversidad de Zaragoza 000095465 700__ $$aVallès, Joan 000095465 700__ $$aGarnatje, Teresa 000095465 700__ $$0(orcid)0000-0003-0582-5418$$aSales, Esther$$uUniversidad de Zaragoza 000095465 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000095465 7102_ $$15011$$2705$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cÁrea Producción Vegetal 000095465 773__ $$g9, 9 (2020), 1250 [18 pp.]$$tPlants$$x2223-7747 000095465 8564_ $$s2246520$$uhttps://zaguan.unizar.es/record/95465/files/texto_completo.pdf$$yVersión publicada 000095465 8564_ $$s471020$$uhttps://zaguan.unizar.es/record/95465/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000095465 909CO $$ooai:zaguan.unizar.es:95465$$particulos$$pdriver 000095465 951__ $$a2023-09-13-10:50:33 000095465 980__ $$aARTICLE