000095475 001__ 95475
000095475 005__ 20210902121733.0
000095475 0247_ $$2doi$$a10.1039/d0dt02113j
000095475 0248_ $$2sideral$$a119531
000095475 037__ $$aART-2020-119531
000095475 041__ $$aeng
000095475 100__ $$aJohnson, Alice
000095475 245__ $$aHeterobimetallic propargyl gold complexes with p-bound copper or silver with enhanced anticancer activity
000095475 260__ $$c2020
000095475 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095475 5203_ $$aSeveral propargyl functionalised substrates with different heteroatoms (N, O or S) have been used for the preparation of propargyl gold(i) phosphine complexes. The complexes were prepared in high yields either by reaction of the substrate with [Au(acac)PPh3] or by reaction of [AuCl(PPh3)] with potassium hydroxide and the substrate in methanol. Several of the complexes have been characterised by X-ray diffraction showing the presence of secondary bonds such as p-stacking and aurophilic interactions. The reaction of the propargyl gold(i) phosphine complexes with [Cu(NO3)(PPh3)2] or [Ag(OTf)(PPh3)2] afforded heterobimetallic complexes with p-coordination of {Cu(PPh3)2} or {Ag(PPh3)2} to the alkyne bond. When the substituent of the propargyl unit contained more strongly coordinating pyridine moieties, [(PyCH2)2NCH2CCAuPPh3], coordination of the heterometal to the pyridine units occurred, displacing the phosphine groups and giving rise to a dimeric structure. The antiproliferative activity of the complexes against cisplatin resistant lung cancer cell line A549 was determined by MTT assay. The mononuclear gold complexes showed excellent activities with IC50 values < 14 µM. Coordination of copper of silver to the alkynyl fragment resulted in a significant increase in activity suggesting a synergistic effect between the two metal centres.
000095475 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21
000095475 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000095475 590__ $$a4.39$$b2020
000095475 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b8 / 45 = 0.178$$c2020$$dQ1$$eT1
000095475 592__ $$a0.98$$b2020
000095475 593__ $$aInorganic Chemistry$$c2020$$dQ1
000095475 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095475 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000095475 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción$$uUniversidad de Zaragoza
000095475 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000095475 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000095475 773__ $$g49, 33 (2020), 11736-11742$$pDalton Trans.$$tDalton Transactions$$x1477-9226
000095475 8564_ $$s1223690$$uhttps://zaguan.unizar.es/record/95475/files/texto_completo.pdf$$yVersión publicada
000095475 8564_ $$s92897$$uhttps://zaguan.unizar.es/record/95475/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095475 909CO $$ooai:zaguan.unizar.es:95475$$particulos$$pdriver
000095475 951__ $$a2021-09-02-09:36:47
000095475 980__ $$aARTICLE