000095484 001__ 95484
000095484 005__ 20210902121737.0
000095484 0247_ $$2doi$$a10.3389/fbioe.2020.00972
000095484 0248_ $$2sideral$$a119553
000095484 037__ $$aART-2020-119553
000095484 041__ $$aeng
000095484 100__ $$aRibitsch, I.
000095484 245__ $$aLarge Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do
000095484 260__ $$c2020
000095484 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095484 5203_ $$aRapid developments in Regenerative Medicine and Tissue Engineering has witnessed an increasing drive toward clinical translation of breakthrough technologies. However, the progression of promising preclinical data to achieve successful clinical market authorisation remains a bottleneck. One hurdle for progress to the clinic is the transition from small animal research to advanced preclinical studies in large animals to test safety and efficacy of products. Notwithstanding this, to draw meaningful and reliable conclusions from animal experiments it is critical that the species and disease model of choice is relevant to answer the research question as well as the clinical problem. Selecting the most appropriate animal model requires in-depth knowledge of specific species and breeds to ascertain the adequacy of the model and outcome measures that closely mirror the clinical situation. Traditional reductionist approaches in animal experiments, which often do not sufficiently reflect the studied disease, are still the norm and can result in a disconnect in outcomes observed between animal studies and clinical trials. To address these concerns a reconsideration in approach will be required. This should include a stepwise approach using in vitro and ex vivo experiments as well as in silico modeling to minimize the need for in vivo studies for screening and early development studies, followed by large animal models which more closely resemble human disease. Naturally occurring, or spontaneous diseases in large animals remain a largely untapped resource, and given the similarities in pathophysiology to humans they not only allow for studying new treatment strategies but also disease etiology and prevention. Naturally occurring disease models, particularly for longer lived large animal species, allow for studying disorders at an age when the disease is most prevalent. As these diseases are usually also a concern in the chosen veterinary species they would be beneficiaries of newly developed therapies. Improved awareness of the progress in animal models is mutually beneficial for animals, researchers, human and veterinary patients. In this overview we describe advantages and disadvantages of various animal models including domesticated and companion animals used in regenerative medicine and tissue engineering to provide an informed choice of disease-relevant animal models.
000095484 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00563$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI18-00529
000095484 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095484 590__ $$a5.89$$b2020
000095484 591__ $$aMULTIDISCIPLINARY SCIENCES$$b12 / 73 = 0.164$$c2020$$dQ1$$eT1
000095484 592__ $$a1.081$$b2020
000095484 593__ $$aBioengineering$$c2020$$dQ1
000095484 593__ $$aHistology$$c2020$$dQ1
000095484 593__ $$aBiotechnology$$c2020$$dQ1
000095484 593__ $$aBiomedical Engineering$$c2020$$dQ1
000095484 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000095484 700__ $$0(orcid)0000-0002-8969-7726$$aBaptista, P.M.
000095484 700__ $$aLange-Consiglio, A.
000095484 700__ $$aMelotti, L.
000095484 700__ $$aPatruno, M.
000095484 700__ $$aJenner, F.
000095484 700__ $$aSchnabl-Feichter, E.
000095484 700__ $$aDutton, L.C.
000095484 700__ $$aConnolly, D.J.
000095484 700__ $$avan Steenbeek, F.G.
000095484 700__ $$aDudhia, J.
000095484 700__ $$aPenning, L.C.
000095484 773__ $$g8 (2020), 972 1-28$$pFront. Bioeng. Biotechnol.$$tFrontiers in Bioengineering and Biotechnology$$x2296-4185
000095484 8564_ $$s750517$$uhttps://zaguan.unizar.es/record/95484/files/texto_completo.pdf$$yVersión publicada
000095484 8564_ $$s509442$$uhttps://zaguan.unizar.es/record/95484/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095484 951__ $$a2021-09-02-09:39:29
000095484 980__ $$aARTICLE