000095489 001__ 95489
000095489 005__ 20210902121733.0
000095489 0247_ $$2doi$$a10.1186/s12916-020-01671-1
000095489 0248_ $$2sideral$$a119559
000095489 037__ $$aART-2020-119559
000095489 041__ $$aeng
000095489 100__ $$aBae, J.B.
000095489 245__ $$aDoes parity matter in women's risk of dementia? A COSMIC collaboration cohort study
000095489 260__ $$c2020
000095489 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095489 5203_ $$aBACKGROUND: Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. METHODS: We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14, 792 women aged 60¿years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. RESULTS: Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR]¿=¿1.47, 95% confidence interval [CI]¿=¿1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR¿=¿2.99, 95% CI¿=¿1.38-6.47) and Latin America (OR¿=¿1.49, 95% CI¿=¿1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR¿=¿2.15, 95% CI¿=¿1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR¿=¿6.86, 95% CI¿=¿1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR¿=¿1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR¿=¿3.47, 95% CI¿=¿1.44-8.35) in Asia. CONCLUSION: Parity is associated with women''s risk of dementia, though this is not uniform across regions and dementia subtypes.
000095489 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000095489 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095489 590__ $$a8.775$$b2020
000095489 591__ $$aMEDICINE, GENERAL & INTERNAL$$b13 / 169 = 0.077$$c2020$$dQ1$$eT1
000095489 592__ $$a3.463$$b2020
000095489 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000095489 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095489 700__ $$aLipnicki, D.M.
000095489 700__ $$aHan, J.W.
000095489 700__ $$aSachdev, P.S.
000095489 700__ $$aKim, T.H.
000095489 700__ $$aKwak, K.P.
000095489 700__ $$aKim, B.J.
000095489 700__ $$aKim, S.G.
000095489 700__ $$aKim, J.L.
000095489 700__ $$aMoon, S.W.
000095489 700__ $$aPark, J.H.
000095489 700__ $$aRyu, S.H.
000095489 700__ $$aYoun, J.C.
000095489 700__ $$aLee, D.Y.
000095489 700__ $$aLee, D.W.
000095489 700__ $$aLee, S.B.
000095489 700__ $$aLee, J.J.
000095489 700__ $$aJhoo, J.H.
000095489 700__ $$aLlibre-Rodriguez, J.J.
000095489 700__ $$aLlibre-Guerra, J.J.
000095489 700__ $$aValhuerdi-Cepero, A.J.
000095489 700__ $$aRitchie, K.
000095489 700__ $$aAncelin, M.L.
000095489 700__ $$aCarriere, I.
000095489 700__ $$aSkoog, I.
000095489 700__ $$aNajar, J.
000095489 700__ $$aSterner, T.R.
000095489 700__ $$aScarmeas, N.
000095489 700__ $$aYannakoulia, M.
000095489 700__ $$aDardiotis, E.
000095489 700__ $$aMeguro, K.
000095489 700__ $$aKasai, M.
000095489 700__ $$aNakamura, K.
000095489 700__ $$aRiedel-Heller, S.
000095489 700__ $$aRoehr, S.
000095489 700__ $$aPabst, A.
000095489 700__ $$avan Boxtel, M.
000095489 700__ $$aKöhler, S.
000095489 700__ $$aDing, D.
000095489 700__ $$aZhao, Q.
000095489 700__ $$aLiang, X.
000095489 700__ $$aScazufca, M.
000095489 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000095489 700__ $$0(orcid)0000-0003-2284-7862$$aDe-la-Cámara, C.$$uUniversidad de Zaragoza
000095489 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza
000095489 700__ $$aKim, K.W.
000095489 700__ $$afor, Cohort, Studies, of, Memory, in, an, International, Consortium, (COSMIC)
000095489 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000095489 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000095489 773__ $$g18, 1 (2020), 210 1-11$$pBMC Medicine$$tBMC Medicine$$x1741-7015
000095489 8564_ $$s527188$$uhttps://zaguan.unizar.es/record/95489/files/texto_completo.pdf$$yVersión publicada
000095489 8564_ $$s49398$$uhttps://zaguan.unizar.es/record/95489/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095489 909CO $$ooai:zaguan.unizar.es:95489$$particulos$$pdriver
000095489 951__ $$a2021-09-02-09:36:54
000095489 980__ $$aARTICLE