95494 20210902121718.0 doi 10.3390/antiox9080718 sideral 119566 ART-2020-119566 eng Perdices, Lorena Epigallocatechin gallate slows retinal degeneration, reduces oxidative damage, and modifies circadian rhythms in P23H Rats 2020 Access copy available to the general public Unrestricted Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of visual function due to mutations mainly in photoreceptors but also in other retinal cells. Apoptosis, retinal disorganization, and inflammation are common in the progression of the disease. Epigallocatechin gallate (EGCG) has been proved as beneficial in different eye diseases. Pigmented heterozygous P23H rat was used as an animal model of RP. Visual function was assessed by optomotor and electroretinogram (ERG) and circadian rhythms were evaluated by telemetry. Hepatic oxidative damage and antioxidant defenses were assessed using biochemical tests. The visual function of the EGCG P23H group was preserved, with a deterioration in the activity period and lower values in the interdaily stability parameter. Control rats treated with EGCG were less active than the sham group. EGCG increased antioxidant levels in P23H rats but reduced total hepatic antioxidant capacity by almost 42% in control rats compared to the sham group. We conclude that treatment with EGCG improves visual function and antioxidant status in P23H rats but diminishes antioxidant defenses in wild-type control animals, and slightly worsens activity circadian rhythms. Further studies are necessary to clarify the beneficial effects in disease conditions and in healthy organisms. info:eu-repo/grantAgreement/ES/DGA/B08-17R info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124 info:eu-repo/grantAgreement/ES/ISCIII/RETICS-FEDER-RD16-0008-0016 info:eu-repo/grantAgreement/ES/MINECO-FEDER/BFU2015-67139-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.312 2020 BIOCHEMISTRY & MOLECULAR BIOLOGY 60 / 297 = 0.202 2020 Q1 T1 FOOD SCIENCE & TECHNOLOGY 11 / 144 = 0.076 2020 Q1 T1 CHEMISTRY, MEDICINAL 6 / 63 = 0.095 2020 Q1 T1 1.066 2020 Biochemistry 2020 Q2 Cell Biology 2020 Q2 Physiology 2020 Q2 Molecular Biology 2020 Q2 Clinical Biochemistry 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fuentes-Broto, Lorena Universidad de Zaragoza (orcid)0000-0003-2656-6750 Segura, Francisco Universidad de Zaragoza (orcid)0000-0002-9250-9060 Cuenca, Nicolás Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 9, 8 (2020), 718 1-21 Antioxidants Antioxidants 2076-3921 4628939 http://zaguan.unizar.es/record/95494/files/texto_completo.pdf Versión publicada 499261 http://zaguan.unizar.es/record/95494/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:95494 articulos driver 2021-09-02-09:26:16 ARTICLE