000095528 001__ 95528
000095528 005__ 20220426091132.0
000095528 0247_ $$2doi$$a10.1109/TBME.2020.3025908
000095528 0248_ $$2sideral$$a119981
000095528 037__ $$aART-2020-119981
000095528 041__ $$aeng
000095528 100__ $$0(orcid)0000-0002-1297-0691$$aKontaxis, Spyridon$$uUniversidad de Zaragoza
000095528 245__ $$aPhotoplethysmographic waveform analysis for autonomic reactivity assessment in depression
000095528 260__ $$c2020
000095528 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095528 5203_ $$aObjective: In the present study, a photoplethysmographic (PPG) waveform analysis for assessing differences in autonomic reactivity to mental stress between patients with Major Depressive Disorder (MDD) and healthy control (HC) subjects is presented. Methods: PPG recordings of 40 MDD and 40 HC subjects were acquired at basal conditions, during the execution of cognitive tasks, and at the post-task relaxation period. PPG pulses are decomposed into three waves (a main wave and two reflected waves) using a pulse decomposition analysis. Pulse waveform characteristics such as the time delay between the position of the main wave and reflected waves, the percentage of amplitude loss in the reflected waves, and the heart rate (HR) are calculated among others. The intra-subject difference of a feature value between two conditions is used as an index of autonomic reactivity. Results: Statistically significant individual differences from stress to recovery were found for HR and the percentage of amplitude loss in the second reflected wave ( A13 ) in both HC and MDD group. However, autonomic reactivity indices related to A13 reached higher values in HC than in MDD subjects (Cohen's d =0.81, AUC = 0.74), implying that the stress response in depressed patients is reduced. A statistically significant (p < 0.001) negative correlation (r = 0.5) between depression severity scores and A13 was found. Conclusion: A decreased autonomic reactivity is associated with higher degree of depression. Significance: Stress response quantification by dynamic changes in PPG waveform morphology can be an aid for the diagnosis and monitoring of depression.
000095528 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/RTI2018-097723-B-I00$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 745755-WECARMON$$9info:eu-repo/grantAgreement/EC/H2020/745755/EU/Wearable Cardiorespiratory Monitor/WECARMON$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS
000095528 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000095528 590__ $$a4.538$$b2020
000095528 591__ $$aENGINEERING, BIOMEDICAL$$b24 / 90 = 0.267$$c2020$$dQ2$$eT1
000095528 592__ $$a1.147$$b2020
000095528 593__ $$aBiomedical Engineering$$c2020$$dQ1
000095528 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000095528 700__ $$0(orcid)0000-0001-7285-0715$$aGil, Eduardo$$uUniversidad de Zaragoza
000095528 700__ $$aMarozas, Vaidotas
000095528 700__ $$0(orcid)0000-0001-8742-0072$$aLázaro, Jesús$$uUniversidad de Zaragoza
000095528 700__ $$aGarcía, Esther
000095528 700__ $$aPosadas-de Miguel, Mar
000095528 700__ $$aSiddi, Sara
000095528 700__ $$0(orcid)0000-0002-8222-1418$$aBernal, María Luisa$$uUniversidad de Zaragoza
000095528 700__ $$aAguiló, Jordi
000095528 700__ $$aHaro, Josep María
000095528 700__ $$0(orcid)0000-0003-2284-7862$$ade la Cámara, Concepción$$uUniversidad de Zaragoza
000095528 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000095528 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000095528 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000095528 7102_ $$11012$$2315$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Farmacología
000095528 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000095528 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000095528 773__ $$g68, 4 (2020), 1273 - 1281$$pIEEE trans. biomed. eng.$$tIEEE Transactions on Biomedical Engineering$$x0018-9294
000095528 8564_ $$s737729$$uhttps://zaguan.unizar.es/record/95528/files/texto_completo.pdf$$yPostprint
000095528 8564_ $$s19448$$uhttps://zaguan.unizar.es/record/95528/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000095528 909CO $$ooai:zaguan.unizar.es:95528$$particulos$$pdriver
000095528 951__ $$a2022-04-26-08:52:04
000095528 980__ $$aARTICLE