000095541 001__ 95541 000095541 005__ 20230323131624.0 000095541 0247_ $$2doi$$a10.1039/d0ra04361c 000095541 0248_ $$2sideral$$a119560 000095541 037__ $$aART-2020-119560 000095541 041__ $$aeng 000095541 100__ $$aGu, Y. 000095541 245__ $$aMagnetic hyperthermia with e-Fe2O3 nanoparticles 000095541 260__ $$c2020 000095541 5060_ $$aAccess copy available to the general public$$fUnrestricted 000095541 5203_ $$aBiocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (ε-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been considered so far, in spite of its unique magnetic properties: ε-Fe2O3. Indeed, whereas Fe3O4 and ε-Fe2O3 have a relatively low magnetic coercivity, ε-Fe2O3 exhibits a giant coercivity. In this report, the heating power of ε-Fe2O3 nanoparticles in comparison with ε-Fe2O3 nanoparticles of similar size (~20 nm) was measured in a wide range of field frequencies and amplitudes, in uncoated and polymer-coated samples. It was found that ε-Fe2O3 nanoparticles primarily heat in the low-frequency regime (20-100 kHz) in media whose viscosity is similar to that of cell cytoplasm. In contrast, ε-Fe2O3 nanoparticles heat more effectively in the high frequency range (400-900 kHz). Cell culture experiments exhibited no toxicity in a wide range of nanoparticle concentrations and a high internalization rate. In conclusion, the performance of ε-Fe2O3 nanoparticles is slightly inferior to that of ¿-Fe2O3 nanoparticles in human magnetic hyperthermia applications. However, these ε-Fe2O3 nanoparticles open the way for switchable magnetic heating owing to their distinct response to frequency. 000095541 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E11-17R$$9info:eu-repo/grantAgreement/EC/H2020/801305/EU/Nanoparticles-based 2D thermal bioimaging technologies/NanoTBTech$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801305-NanoTBTech$$9info:eu-repo/grantAgreement/EC/H2020/829162/EU/Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation/HOTZYMES$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 829162-HOTZYMES$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PGC2018-095795-B-I00 000095541 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000095541 590__ $$a3.361$$b2020 000095541 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b81 / 178 = 0.455$$c2020$$dQ2$$eT2 000095541 592__ $$a0.746$$b2020 000095541 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1 000095541 593__ $$aChemical Engineering (miscellaneous)$$c2020$$dQ1 000095541 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000095541 700__ $$aYoshikiyo, M. 000095541 700__ $$aNamai, A. 000095541 700__ $$aBonvin, D. 000095541 700__ $$0(orcid)0000-0002-8797-0813$$aMartinez, A.$$uUniversidad de Zaragoza 000095541 700__ $$0(orcid)0000-0001-7625-4806$$aPiñol, R.$$uUniversidad de Zaragoza 000095541 700__ $$0(orcid)0000-0002-1819-4785$$aTéllez, P.$$uUniversidad de Zaragoza 000095541 700__ $$aSilva, N.J.O. 000095541 700__ $$aAhrentorp, F. 000095541 700__ $$aJohansson, C. 000095541 700__ $$aMarco-Brualla, J. 000095541 700__ $$0(orcid)0000-0002-6600-1618$$aMoreno-Loshuertos, R.$$uUniversidad de Zaragoza 000095541 700__ $$0(orcid)0000-0001-8971-7355$$aFernández-Silva, P.$$uUniversidad de Zaragoza 000095541 700__ $$aCui, Y. 000095541 700__ $$aOhkoshi, S.I. 000095541 700__ $$0(orcid)0000-0003-0828-3212$$aMillán, A.$$uUniversidad de Zaragoza 000095541 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica 000095541 7102_ $$10$$2X$$aUniversidad de Zaragoza$$bServ.Gral. Apoyo Investigación$$cDivisión: Serv. Transversales 000095541 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000095541 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada 000095541 773__ $$g10, 48 (2020), 28786-28797$$pRSC ADVANCES$$tRSC Advances$$x2046-2069 000095541 8564_ $$s1746103$$uhttps://zaguan.unizar.es/record/95541/files/texto_completo.pdf$$yVersión publicada 000095541 8564_ $$s63712$$uhttps://zaguan.unizar.es/record/95541/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000095541 909CO $$ooai:zaguan.unizar.es:95541$$particulos$$pdriver 000095541 951__ $$a2023-03-23-12:57:29 000095541 980__ $$aARTICLE