000095634 001__ 95634
000095634 005__ 20210902121756.0
000095634 0247_ $$2doi$$a10.1016/j.anpede.2019.05.009
000095634 0248_ $$2sideral$$a118915
000095634 037__ $$aART-2020-118915
000095634 041__ $$aeng
000095634 100__ $$aRodríguez-Vigil Iturrate, C
000095634 245__ $$aPrimary immune thrombocytopenia: Experience of a specialised clinic
000095634 260__ $$c2020
000095634 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095634 5203_ $$aIntroduction: Although primary immune thrombocytopenia (ITP) is rare in childhood, it is the most frequent cause of thrombocytopenia. There have been attempts to establish risk factors to predict the progression of the disease in order to optimise its management, which has changed in recent years due to, among other reasons, specialised care.
Material and methods: A retrospective, observational and analytical study was conducted on patients diagnosed with ITP over a 3-year period in a Paediatric Haematology specialist clinic.
Results: From the epidemiological, clinical and analytical point of view, the characteristics of this group are similar to others. Most of the patients (23/31, 74.2%) had ITP for less than 12 months, with there being no serious complications related to the disease or the treatment received. It was established that risk factors were related to being slowly evolving (lower event free survival (EFS)) with no statistical significance, female gender, age over 10 years, leukopenia absence of initial severe thrombocytopenia, and non-specialised care. The absence of a history of infection was significantly related to a lower EFS.
Conclusions: The epidemiological and analytical risk factors for a slowly evolving ITP are the same that described in the literature. Patients treated before the beginning of specialised care also had a lower EFS. These data seem to support the current recommendation that rare diseases should be managed in specialised units. (C) 2019 Published by Elsevier Espana, S.L.U. on behalf of Asociaci6n Espanola de Pediatria. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
000095634 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000095634 590__ $$a1.5$$b2020
000095634 591__ $$aPEDIATRICS$$b100 / 129 = 0.775$$c2020$$dQ4$$eT3
000095634 592__ $$a0.226$$b2020
000095634 593__ $$aPediatrics, Perinatology and Child Health$$c2020$$dQ3
000095634 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095634 700__ $$aSanz de Miguell, MP
000095634 700__ $$aMartínez Faci, C
000095634 700__ $$aMurillo Sanjuan, L
000095634 700__ $$aCalvo Escribano, C
000095634 700__ $$aGarcía Íñiguez, JP
000095634 700__ $$0(orcid)0000-0001-5492-3191$$aSamper Villagrasa, MP$$uUniversidad de Zaragoza
000095634 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000095634 773__ $$g93, 1 (2020), 16-23$$pAn. pediatr.$$tAnales de Pediatria$$x1695-4033
000095634 8564_ $$s338772$$uhttps://zaguan.unizar.es/record/95634/files/texto_completo.pdf$$yVersión publicada
000095634 8564_ $$s37992$$uhttps://zaguan.unizar.es/record/95634/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095634 909CO $$ooai:zaguan.unizar.es:95634$$particulos$$pdriver
000095634 951__ $$a2021-09-02-09:51:58
000095634 980__ $$aARTICLE