000095638 001__ 95638
000095638 005__ 20230519145354.0
000095638 0247_ $$2doi$$a10.1016/j.neuroscience.2020.03.011
000095638 0248_ $$2sideral$$a119818
000095638 037__ $$aART-2021-119818
000095638 041__ $$aeng
000095638 100__ $$aSánchez-Vives, María V.
000095638 245__ $$aGABAB receptors modulation of thalamocortical dynamics and synaptic plasticity
000095638 260__ $$c2021
000095638 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095638 5203_ $$aGABAB-receptors (GABAB-Rs) are metabotropic, G protein-coupled receptors for the neurotransmitter GABA. Their activation induces slow inhibitory control of the neuronal excitability mediated by pre- and postsynaptic inhibition. Presynaptically GABAB-Rs reduce GABA and glutamate release inhibiting presynaptic Ca2+ channels in both inhibitory and excitatory synapses while postsynaptic GABAB-Rs induce robust slow hyperpolarization by the activation of K+ channels. GABAB-Rs are activated by non-synaptic or volume transmission, which requires high levels of GABA release, either by the simultaneous discharge of GABAergic interneurons or very intense discharges in the thalamus or by means of the activation of a neurogliaform interneurons in the cortex. The main receptor subunits GABAB1a, GABAB1b and GABAB2 are strongly expressed in neurons and glial cells throughout the central nervous system and GABAB-R activation is related to many neuronal processes such as the modulation of rhythmic activity in several brain regions. In the thalamus, GABAB-Rs modulate the generation of the main thalamic rhythm, spindle waves. In the cerebral cortex, GABAB-Rs also modulate the most prominent emergent oscillatory activity—slow oscillations—as well as faster oscillations like gamma frequency. Further, recent studies evaluating the complexity expressed by the cortical network, a parameter associated with consciousness levels, have found that GABAB-Rs enhance this complexity, while their blockade decreases it. This review summarizes the current results on how the activation of GABAB-Rs affects the interchange of information between brain areas by controlling rhythmicity as well as synaptic plasticity.
000095638 536__ $$9info:eu-repo/grantAgreement/EC/H2020/785907/EU/Human Brain Project Specific Grant Agreement 2/HBP SGA2$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 785907-HBP SGA2$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2017-85048-R$$9info:eu-repo/grantAgreement/ES/MINECO/PCIN-2015-162-C02-01
000095638 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
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000095638 594__ $$a6.4$$b2021
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000095638 593__ $$aNeuroscience (miscellaneous)$$c2021$$dQ2
000095638 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000095638 700__ $$aBarbero-Castillo, Almudena
000095638 700__ $$0(orcid)0000-0002-3194-7796$$aPérez-Zabalza, María$$uUniversidad de Zaragoza
000095638 700__ $$aReig, Ramón
000095638 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000095638 773__ $$g456 (2021), 131-142$$pNeuroscience$$tNEUROSCIENCE$$x0306-4522
000095638 8564_ $$s2035822$$uhttps://zaguan.unizar.es/record/95638/files/texto_completo.pdf$$yVersión publicada
000095638 8564_ $$s36986$$uhttps://zaguan.unizar.es/record/95638/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000095638 951__ $$a2023-05-18-13:30:35
000095638 980__ $$aARTICLE