000095687 001__ 95687
000095687 005__ 20201009203728.0
000095687 0247_ $$2doi$$a10.25259/SNI_272_2020
000095687 0248_ $$2sideral$$a120313
000095687 037__ $$aART-2020-120313
000095687 041__ $$aeng
000095687 100__ $$aSánchez-Ortega, J.F.
000095687 245__ $$aGlioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
000095687 260__ $$c2020
000095687 5060_ $$aAccess copy available to the general public$$fUnrestricted
000095687 5203_ $$aBackground: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. 
Case Description: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC. 
Conclusion: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.
000095687 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000095687 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000095687 700__ $$0(orcid)0000-0001-5821-3920$$aAguas-Valiente, J.$$uUniversidad de Zaragoza
000095687 700__ $$aSota-Ochoa, P.$$uUniversidad de Zaragoza
000095687 700__ $$0(orcid)0000-0003-3883-3094$$aCalatayud-Pérez, J.$$uUniversidad de Zaragoza
000095687 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000095687 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000095687 773__ $$g11 (2020), 178 [5 pp]$$tSurgical Neurology International$$x2152-7806
000095687 8564_ $$s343138$$uhttps://zaguan.unizar.es/record/95687/files/texto_completo.pdf$$yVersión publicada
000095687 8564_ $$s57177$$uhttps://zaguan.unizar.es/record/95687/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000095687 909CO $$ooai:zaguan.unizar.es:95687$$particulos$$pdriver
000095687 951__ $$a2020-10-09-17:45:46
000095687 980__ $$aARTICLE