000095744 001__ 95744 000095744 005__ 20220425105232.0 000095744 0247_ $$2doi$$a10.1038/s41572-020-0153-5 000095744 0248_ $$2sideral$$a117702 000095744 037__ $$aART-2020-117702 000095744 041__ $$aeng 000095744 100__ $$aTursi, Antonio 000095744 245__ $$aColonic diverticular disease 000095744 260__ $$c2020 000095744 5060_ $$aAccess copy available to the general public$$fUnrestricted 000095744 5203_ $$aDiverticula are outpouchings of the intestinal wall and are common anatomical alterations detected in the human colon. Colonic diverticulosis (the presence of diverticula in the colon; referred to as diverticulosis) remains asymptomatic in most individuals but ~25% of individuals will develop symptomatic diverticulosis, termed colonic diverticular disease (also known as diverticular disease). Diverticular disease can range in severity from symptomatic uncomplicated diverticular disease (SUDD) to symptomatic disease with complications such as acute diverticulitis or diverticular haemorrhage. Since the early 2000s, a greater understanding of the pathophysiology of diverticulosis and diverticular disease, which encompasses genetic alterations, chronic low-grade inflammation and gut dysbiosis, has led to improvements in diagnosis and management. Diagnosis of diverticular disease relies on imaging approaches, such as ultrasonography, CT and MRI, as biomarkers alone are insufficient to establish a diagnosis despite their role in determining disease severity and progression as well as in differential diagnosis. Treatments for diverticular disease include dietary fibre, pharmacological treatments such as antibiotics (rifaximin), anti-inflammatory drugs (mesalazine) and probiotics, alone or in combination, and eventually surgery. Despite being effective in treating primary disease, their effectiveness in primary and secondary prevention of complications is still uncertain. 000095744 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000095744 590__ $$a52.329$$b2020 000095744 591__ $$aMEDICINE, GENERAL & INTERNAL$$b4 / 169 = 0.024$$c2020$$dQ1$$eT1 000095744 592__ $$a10.718$$b2020 000095744 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000095744 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000095744 700__ $$aScarpignato, Carmelo 000095744 700__ $$aStrate, Lisa L. 000095744 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Ángel$$uUniversidad de Zaragoza 000095744 700__ $$aKruis, Wolfgang 000095744 700__ $$aLahat, Adi 000095744 700__ $$aDanese, Silvio 000095744 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000095744 773__ $$g6, 20 (2020)$$pNat. rev., Dis. primers$$tNature Reviews Disease Primers$$x2056-676X 000095744 8564_ $$s623949$$uhttps://zaguan.unizar.es/record/95744/files/texto_completo.pdf$$yPostprint 000095744 8564_ $$s371466$$uhttps://zaguan.unizar.es/record/95744/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000095744 909CO $$ooai:zaguan.unizar.es:95744$$particulos$$pdriver 000095744 951__ $$a2022-04-25-10:37:05 000095744 980__ $$aARTICLE